DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and si:dkey-105h12.2

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	XP_001345438.6	Gene:	si:dkey-105h12.2 / 100006782	ZFINID:	ZDB-GENE-131118-9	Length:	1447	Species:	Danio rerio

Alignment Length:	1697	Identity:	353/1697 - (20%)
Similarity:	628/1697 - (37%)	Gaps:	436/1697 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 EPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMR--- 190
            ||::.::...::..|...::..|:|.....:.::..:.              .|...|||::
Zfish    35 EPSFMVIFPAVIESGSEAKLCASLLNPNESLVMNIYLV--------------HGNQSTLLLQEKA 85

  Fly   191 ----------IPPTSVTGSYK-LRVEGFYQNVFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYM 242
                      ..|.:|..|.: ::||      ..|.:|  ..|.::.|.......|:|||||:|:
Zfish    86 EQEFHRCFNFKAPLAVAESVQIMKVE------LQGESFKRTEERKVMFKSYHPLTFIQTDKPIYI 144

  Fly   243 QGETVRFRTIPITTELKGFDNPV-DVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWT 306
            .|:||.||.:.:.......|... .|.:.|...:.:.:|.:..|....:...|:|:.:...|.:.
Zfish   145 PGQTVNFRIVTLDKNFAPLDQQYSSVVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGTYK 209

  Fly   307 IRVIAQGQQEESH-FTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKAT 370
            ::... |::..|| |.|::|...:|||.|..|......:..:...|.|.:|.|.||.|...:|..
Zfish   210 LKAFI-GERMISHYFKVKKYVLPKFEVAVKKPNKVSVDEEELLIEVCAKYTYGQPVPGKSWVKVC 273

  Fly   371 IRPIGYFSNQVLNEKYRLGRSPL---EQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQD 432
            ...:.:|..:..|        ||   |.|.:.......:|        :.:.
Zfish   274 RNSMRHFHTKDFN--------PLCSEETTEITKAGCAIHN--------FGIS------------- 309

  Fly   433 ILYRNQYVVER-----HYQ---FDEEWPFWVRKPEYQDSSYEAWSGT---YRKTLPYLRYFNG-- 484
             ::.|..:.||     |.:   .:|.....:.|.|....:||....|   ..||..:.....|
Zfish   310 -VFLNSTLKERLMNSLHVEAVVTEEGTEITMTKSESVPLTYEIGKVTLIDLPKTYEHGSVIEGKI 373

  Fly   485 -TFDFK---WPLRELELLVPNLANSEVLI---------------TATVGEKFYDEIISGY--SVA 528
             .||||   .|.:|:.||.....:|::|:               |:::.:|....|.|.|  :..
Zfish   374 KLFDFKDAPIPNKEVYLLEGENWSSKLLLNLTTDSDGLASFSLNTSSLSKKDISLIASVYPDTHF 438

  Fly   529 RVYNSSLRVVFLGD--SPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRR 591
            |.|.:.   .|..|  :.|||:.|.|:|..|
Zfish   439 REYKTP---YFSTDKKTVQVFQTADPYTPIL---------------------------------- 466

  Fly   592 DWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLL 656
                                                                        :||::
Zfish   467 ------------------------------------------------------------SELIM 471

  Fly   657 VSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFN----YLIMSKGVILVNDRE------ 711
            .:...|.....::|.:.:...|||.:          |.||    |:::|||||:.:..|
Zfish   472 ENIEQPIKCGTEITATVKYYFVGETV----------EGFNTDIVYIVLSKGVIVRHGYEKLEVKS 526

  Fly   712 ---TITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKART 773
               .::.|..:..:.:.:::|||..|:|:.:.....:||.:....:.....|..::..:..||..
Zfish   527 SSNRVSSGTVSFKLSVGADVAPVVQILVYCVLPSENIVAANKRLSIEKCFGNKVSLQFSPAKAVP 591

  Fly   774 GEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKI-----ITKMSNF-----DEQ------ 822
            |||..:.:..:|||..|||.:|.:...:::|..|...||     :..:|.:     |||
Zfish   592 GEKNTLQLSAQPGSLCGLSAVDQSVLILESGKRLDADKIFNLLPVQSVSYYPYSVEDEQPCLHVR 656

  Fly   823 ------TNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLI----VFTDGYVPRRQDTC 877
                  |:..|:        |...:....||:..|.......|.||.    :...|.|    :|.
Zfish   657 PRRSVLTDNVYE--------NLKRVGLKMASNLFVRVPECLSYRGLTYHRKIARTGVV----NTA 709

  Fly   878 NRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLW 942
            ...:||                               :|.::.|:| |......:...:...|:|
Zfish   710 RSRMGF-------------------------------SRPESSLVN-RDSPTVTIRTVFPETWIW 742

  Fly   943 KDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQG 1007
            ....:|..|.....|.|||....|...||.:| |.|.|:...| :....||||:.:.:|.:..:|
Zfish   743 DLAEVGDSGSAEVPVTVPDTITTWETEAFCLS-STGLGLAPPA-QLTVFQPFFLELSLPYSIIRG 805

  Fly  1008 EQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSY------NPRTSF---------G 1057
            |...::.|||||:...|...|....|.||......:|    .|      |.|.:|         |
Zfish   806 EIFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDD----QYSSCLCANGRQTFKWILTPSVLG 866

  Fly  1058 EHQFFIYLEAQGTTVV---YVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSV 1119
            .....:..||:.:..|   .:..||:| |.:|:            :||:|.|:::|..:....|.
Zfish   867 VMNITVSAEAEASQTVCDNEIVSVPER-GRIDI------------VTRSLLVQAEGTEKTETNSW 918

  Fly  1120 LL-----DLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNAS 1179
            ||     .||.        .:|:|    :|..|    :.||.|:.:||:||::|....    |..
Zfish   919 LLCPKGDSLSE--------EMNLT----LPKDV----IEGSAKSSVSVIGDILGRALQ----NLH 963

  Fly  1180 SLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLF 1244
            .||.:|...||||....:.|:|.:.|:....|....:.:.|...:..||||||::...||::|.|
Zfish   964 GLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTF 1028

  Fly  1245 RSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPD 1309
                ...|.:.|||::.|:.|.:|     :.:.:||..||:....||:..:...|.|.:...|.:
Zfish  1029 ----GYGDGNTWLTAFVLKSFGKA-----QKYTFIDPQIIQSAKDWLISRRNSDGCFIQQGRLFN 1084

  Fly  1310 RKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQ----PF 1370
            .:| :...:.|:|:|:::..:|             :.|.|......|.:.:..||...:    .:
Zfish  1085 NRM-KGGVNNNVTMTAYITASL-------------LELETPVTDPVITKGLSCLRSVIEDVKNTY 1135

  Fly  1371 DVAITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEY 1434
            ..|:.||...|. ::...:::|..|...|.:.|..::|.......                  :.
Zfish  1136 TTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSASAD------------------DS 1182

  Fly  1435 DSLNIETTAYALLVYVARREF------FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVR 1493
            .||::|.::|.||..:.....      |.:.||.||..|:...||::|||||..||:||..|..:
Zfish  1183 ASLDVEISSYVLLAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATK 1247

  Fly  1494 SRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQY 1558
            ....:.|| ||.::::   |.:....::..|....|..::.:..|...::.||:....:||...|
Zfish  1248 VFSSDGSS-TVTVQSA---GDSHHFDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQMAQFY 1308

  Fly  1559 NVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNW--INQNESERSGMAVLDVAIPTGYW 1621
            |:       ..|..|..|...|...|..:.........|:  .......::.|.::|:.:.:|:
Zfish  1309 NI-------LTPTEAKTLSIDAEVEGDCKKTFGKSLLLNFTVTYDGPQAKTNMVIVDIKLLSGF- 1365

  Fly  1622 IQQQKLDTYVLSNRVRN----LRRARYLERKIVFYFDYLDHED-ICVNFTIERWYPVANMSRYLP 1681
                ..||.:|..:.::    :.|....:..::.|...:...| :.:...:.:...|.|:...:
Zfish  1366 ----TADTSMLKTQQQSYASPVERIDSKDDHVLVYLKEVPKADPVNLQIGLNQIIQVKNLKPAV- 1425

  Fly  1682 VRIYDYY 1688
            :::||||
Zfish  1426 IKVYDYY 1432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	27/101 (27%)
		A2M_N_2	669..799	CDD:285005	35/142 (25%)
		LDLa	886..913	CDD:238060	0/26 (0%)
		A2M	940..1030	CDD:278630	30/89 (34%)
		ISOPREN_C2_like	1177..1490	CDD:298658	81/323 (25%)
		A2M_comp	1226..1492	CDD:284982	69/276 (25%)
		A2M_recep	1607..1695	CDD:284981	15/87 (17%)
si:dkey-105h12.2	XP_001345438.6	A2M_N	134..225	CDD:280081	24/91 (26%)
		A2M_N_2	476..617	CDD:285005	36/150 (24%)
		A2M	739..827	CDD:278630	29/89 (33%)
		A2M_2	958..1244	CDD:239227	81/330 (25%)
		A2M_comp	1010..1246	CDD:284982	69/276 (25%)
		A2M_recep	1352..1442	CDD:284981	15/87 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11188
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920