DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	133/564 - (23%)
Similarity:	260/564 - (46%)	Gaps:	83/564 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CLRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQ 68
            |.:||                :.|.:| |:| ..:||:..:..||.||..:||::||:    .|.
  Rat    17 CFKSG----------------NCGKVL-VWP-MEYSHWMNIKIILEELVQKGHEVTVL----RPS 59

  Fly    69 AGAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDL--HEEGQKTCEHLFASG 131
            |..:.:.:|           ::.:..|.......:..|......:|::  :|..:.||...|.
  Rat    60 ASVFLDPKE-----------TSDLKFVTFPTSFSSHDLENFFTRFVNVWTYELPRDTCLSYFL-- 111

  Fly   132 HIERAIERH---------------------RNKPYDLLLTEYFNSDCQLALAKLLNLPI---IGL 172
            :::..|:.:                     :...:|::.::.. ..|...:|:||.:|.   :..
  Rat   112 YLQDTIDEYSDYCLTVCKEAVSNKQFMTKLQESKFDVVFSDAI-GPCGELIAELLQIPFLYSLRF 175

  Fly   173 STCALMPYYYDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVR 237
            |....:..|...:..|  |:::...|.|.|||:.:.||:.|.:......|.::....:..:....
  Rat   176 SPGYTIEKYIGGVLFP--PSYVPMIFSGLAGQMTFIERVHNMICMLYFDFWFQTFREKKWDPFYS 238

  Fly   238 KYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQS 302
            |.||....:.|:......::. ..::.|....|.|.....|||:|.  |..:.||::|.:|:..|
  Rat   239 KTLGRPTTLAEIMGKAEMWLI-RSYWDLEFPHPISPNVDYIGGLHC--KPAKPLPKDIEDFVQSS 300

  Fly   303 AE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLA 366
            .| ||:..|.|||||  ::.|:|.:.|...|...|.|::|:::..:.|....:..|: ||.||..
  Rat   301 GEHGVVVFSLGSMVR--NMTEEKANIIAWALAQIPQKVLWRFDGKKPPTLGPNTRLY-KWLPQND 362

  Fly   367 LLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLK 431
            ||.|||.|.|.:|||..|..|::|.|.|::..|::|:|..|...:..:|..::::::.::..::.
  Rat   363 LLGHPKTKAFVTHGGANGIYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDML 427

  Fly   432 KALAELSKNS-YAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYH 495
            .||.|:..|. |.:.::.:|.:.:::...||:.|::.:|.|:.:.  .|:.|:|.|..|..:.||
  Rat   428 NALEEVINNPFYKKNAMWLSTIHHDQPTKPLDRAVFWIEFVMRHK--GAKHLRSLGHNLPWYQYH 490

  Fly   496 SLDSVALIL--LPLILLILVLCYLCKRNPSKLAHKKVGKKPKRS 537
            |||.:..:|  :.:.:::.:.|:|       ..::...||.|::
  Rat   491 SLDVIGFLLTCVAVTVVLALKCFL-------FVYRFFVKKEKKT 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	115/494 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	120/490 (24%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	130/539 (24%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	70/225 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840