DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	570	Identity:	133/570 - (23%)
Similarity:	247/570 - (43%)	Gaps:	92/570 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CLRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVIS-----Y 63
            ||.|  |:.||.|..|       |.:| |:|..| ||:..:..::.||..:||::||:.     |
Zfish     8 CLFS--LLCVLSGTYG-------GKVL-VFPLDG-SHWVNMKVLIEELHRKGHNVTVVRPSNSWY 61

  Fly    64 VKNPQAGAYPNYEELLISAPG---EDQSSTTINLVPLTEHTPTRSLGV----------------L 109
            :|...    |.|..:.|...|   |:.|...||          |.|.:                :
Zfish    62 IKEES----PFYSSITIPNTGGFDEEFSGLLIN----------RLLEIKRGGYFVLNRVRLEFEI 112

  Fly   110 IREYVDLHEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPII---- 170
            :.::..:||:..:..:.:...   |:.:...::..:|::|.:.......: ||...|:|::
Zfish   113 MMKFKTMHEDMLQMMDRMLED---EKVMNSIQDAKFDVVLADPAVGGGPI-LAYKFNIPLVFNVR 173

  Fly   171 ------GLSTCALMPYYY---DRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLL-KFLYK 225
                  |....|..|..|   ..::|.|..:|:|.       ..|....|::.:|.::: :.:|.
Zfish   174 WTIQGEGHFAIAPSPLSYIPVPGVELTDKMSFLQR-------VKNVLIYLISQIQMQIMVEPIYA 231

  Fly   226 YHSNRADNELVRKYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQE 290
                    ....|:.|..|....:.:....::..|. ::....||.....|.:.|...  |..:.
Zfish   232 --------PFCHKHFGPNVTYFSLFQDADIWLMRND-FTFEFPRPTMPNIVYMSGFQC--KPAKP 285

  Fly   291 LPQNIANFLNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDAS 354
            ||.::..|:..|.| |||.:|.|:::  :.:.:|....|.......|.|:||::.... |.|..:
Zfish   286 LPNDLEKFVESSGEHGVIVMSLGTLI--AQLPQDMTDDIAAAFAELPQKVIWRYTGPR-PVTLGN 347

  Fly   355 KFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLK 419
            ..|.|:|.||..||.||::|:|.:|||..|..|:::.|.|:|..|:..||..|.|.::.:|....
Zfish   348 NTLLVEWLPQNDLLGHPQIKVFVAHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKI 412

  Fly   420 LDYQDITVPNLKKALAELSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQ 483
            :|...:......:||.|:..| ||.:....:||:.:::...||:.|::.:|.|:.|.  .|..|:
Zfish   413 VDIATLDKTVFLEALKEVLYNPSYRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNK--GAPHLR 475

  Fly   484 SPGIELNGFVYHSLDSVALILLPLILLILVLCYLCKRNPSKLAHKKVGKK 533
            :....::...|||:|.:..:::...:..|::.|..|.....:..|||.::
Zfish   476 TQSFRMSWIEYHSIDVILTLMVTGFVFALMIGYTIKYFCLCVFRKKVKRE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	117/506 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	114/502 (23%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	125/545 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840