Protein Alignment Ugt36A1 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_524686.3
• Gene: Ugt36A1 / 44058
• FlyBaseID: FBgn0015663
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 150/568 - (26%)
• Similarity: 254/568 - (44%)
• Gaps: 80/568 - (14%)

  Fly     1 MTTCLRS------GVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDIT 59
            |...|||      ||..:.|.|::       .|:.|.|.|..| ||:..:..|:..|:.|||:|.
Human     1 MACLLRSFQRISAGVFFLALWGMV-------VGDKLLVVPQDG-SHWLSMKDIVEVLSDRGHEIV 57

  Fly    60 VISYVKNPQAGAYPNYEELLISAPGEDQ--------------SSTTINLVPLTEHTPTRSLGVLI 110
            |:....|........|...:...|.:.:              :..:....|.||:   |:..::|
Human    58 VVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEY---RNNMIVI 119

  Fly   111 REYVDLHEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGL--- 172
            ..|.       ..|:.|...   ...:...:...:|.|.|:. ...|.:.||:.|.||.:.|
Human   120 GLYF-------INCQSLLQD---RDTLNFFKESKFDALFTDP-ALPCGVILAEYLGLPSVYLFRG 173

  Fly   173 STCALMPYYYDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLY-----KYHSNRAD 232
            ..|:| .:.:.|  .||..::|...:..|:..:.:.:|:.||:...|..:|:     ||
Human   174 FPCSL-EHTFSR--SPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKY------ 229

  Fly   233 NELVRKYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIAN 297
            .||....|..:||:..:.:..:.::. ...:.|...||.....|.|||::..|:  ::|.|....
Human   230 EELASAVLKRDVDIITLYQKVSVWLL-RYDFVLEYPRPVMPNMVFIGGINCKKR--KDLSQEFEA 291

  Fly   298 FLNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKW 361
            ::|.|.| |::..|.||||  |.|.|.|..||.:.|...|..::|::.... |...|:..:.|||
Human   292 YINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTR-PSNLANNTILVKW 353

  Fly   362 APQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDIT 426
            .||..||.||..:.|.:|.|..|..||:..|.|:::.|::|||..||..::.:|.|:.|:..::|
Human   354 LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT 418

  Fly   427 VPNLKKAL-AELSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELN 490
            ..:|:.|| |.::..||.:..:.:|.:..:|...||:.|::.||.|:.:.  .|..|:....:|.
Human   419 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHK--GAPHLRPAAHDLT 481

  Fly   491 GFVYHSLDSVALILLPLILLILVLCYLC----------KRNPSKLAHK 528
            .:.|||||.:. .||.::|.:..:.:.|          |:...|.|||
Human   482 WYQYHSLDVIG-FLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_524686.3	GT1_Gtf-like	28..469	CDD:340817	121/464 (26%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	137/528 (26%)