Protein Alignment Ugt36A1 and UGT1A7

DIOPT Version :10

• Sequence 1: NP_524686.3
• Gene: Ugt36A1 / 44058
• FlyBaseID: FBgn0015663
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 137/534 - (25%)
• Similarity: 245/534 - (45%)
• Gaps: 34/534 - (6%)

  Fly    10 LIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYPN 74
            |.:.||...|..:   ||.:|.| |..| ||:..:..::.:|..|||::.|:....:.|.|...|
Human    12 LYVCLLLTCGFAK---AGKLLVV-PMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLN 71

  Fly    75 --YEELLISAPGEDQSSTTINLVPLTEHTPTRS-LGVLIREYVDLHEEGQKTCEHLFASGHIERA 136
              .:....|...|||....:.........|.|| ..:|......:.:.....|..||   :..:.
Human    72 CTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLF---NDRKL 133

  Fly   137 IERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTPAFIQSEFVGF 201
            :|..:...:|.:..:.|:: |.|.:||..:||.:..:......|..:....|...:::....:||
Human   134 VEYLKESCFDAVFLDPFDA-CGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGF 197

  Fly   202 AGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEEVARTQTAFIFGNQHYSLM 266
            :..:.:.||:.|.:. .|.:.|:..:..:...|:..:.|...|...:: .:.|:.......:.|.
Human   198 SDAMTFKERVWNHIM-HLEEHLFCPYFFKNVLEIASEILQTPVTAYDL-YSHTSIWLLRTDFVLE 260

  Fly   267 GSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSIDEDKLSAILE 330
            ..:|.....:.|||::..:  .:.:|.....::|.|.| |::..|.||||  |.|.|.|..||.:
Human   261 YPKPVMPNMIFIGGINCHQ--GKPVPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIAD 321

  Fly   331 VLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPL 395
            .|...|..::|::.... |...|:..:.|||.||..||.||..:.|.:|.|..|..||:..|.|:
Human   322 ALGKIPQTVLWRYTGTR-PSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPM 385

  Fly   396 LVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKAL-AELSKNSYAQRSLEVSKVFNERQQT 459
            ::.|::|||..||..::.:|.|:.|:..::|..:|:.|| |.::..||.:..:.:|.:..:|...
Human   386 VMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVE 450

  Fly   460 PLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALILLPLILLILVLCYLC------ 518
            ||:.|::.||.|:.:.  .|..|:....:|..:.|||||.:. .||.::|.:..:.:.|
Human   451 PLDLAVFWVEFVMRHK--GAPHLRPAAHDLTWYQYHSLDVIG-FLLAVVLTVAFITFKCCAYGYR 512

  Fly   519 ----KRNPSKLAHK 528
                |:...|.|||
Human   513 KCLGKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_524686.3	GT1_Gtf-like	28..469	CDD:340817	111/445 (25%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	128/510 (25%)