Protein Alignment Ugt36A1 and UGT1A8

DIOPT Version :9

• Sequence 1: NP_001285591.1
• Gene: Ugt36A1 / 44058
• FlyBaseID: FBgn0015663
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 139/562 - (24%)
• Similarity: 248/562 - (44%)
• Gaps: 90/562 - (16%)

  Fly    10 LIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYPN 74
            |.:.||...|..|   ||.:|.| |..| ||:..:..::.:|..|||::.|:....:.|.|
Human    12 LCVSLLLTCGFAE---AGKLLVV-PMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLG---- 67

  Fly    75 YEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKT---------------- 123
                           .::|....| ::.:.:|..|.||::|..:...|.
Human    68 ---------------KSLNCTVKT-YSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGF 116

  Fly   124 -------CEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYY 181
                   |..||   :..:.:|..:...:|.:..:.|:: |.|.:||..:||.:..:......|.
Human   117 FNLFFSHCRSLF---NDRKLVEYLKESSFDAVFLDPFDA-CGLIVAKYFSLPSVVFARGIACHYL 177

  Fly   182 YDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDV 246
            .:....|...:::....:||:..:.:.||:.|.:.........:|.|..|          :|:..
Human   178 EEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNA----------LEIAS 232

  Fly   247 EEVARTQTAF-IFGNQHYSLMGS-------RPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSA 303
            |.:....||: ::.:....|:.:       :|.....:.|||::..:  .:.||.....::|.|.
Human   233 EILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQ--GKPLPMEFEAYINASG 295

  Fly   304 E-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLAL 367
            | |::..|.||||  |.|.|.|..||.:.|...|..::|::.... |...|:..:.|||.||..|
Human   296 EHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTR-PSNLANNTILVKWLPQNDL 357

  Fly   368 LCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKK 432
            |.||..:.|.:|.|..|..||:..|.|:::.|::|||..||..::.:|.|:.|:..::|..:|:.
Human   358 LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLEN 422

  Fly   433 AL-AELSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHS 496
            || |.::..||.:..:.:|.:..:|...||:.|::.||.|:.:.  .|..|:....:|..:.|||
Human   423 ALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHK--GAPHLRPAAHDLTWYQYHS 485

  Fly   497 LDSVALILLPLILLILVLCYLC----------KRNPSKLAHK 528
            ||.:. .||.::|.:..:.:.|          |:...|.|||
Human   486 LDVIG-FLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	122/497 (25%)
		UDPGT	38..501	CDD:278624	119/495 (24%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	129/538 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840