Protein Alignment Ugt36A1 and UGT1A10

DIOPT Version :9

• Sequence 1: NP_001285591.1
• Gene: Ugt36A1 / 44058
• FlyBaseID: FBgn0015663
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 142/567 - (25%)
• Similarity: 256/567 - (45%)
• Gaps: 100/567 - (17%)

  Fly    10 LIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI------------- 61
            |.:.||...|..|   ||.:|.| |..| ||:..:..::.:|..|||::.|:
Human    12 LCVCLLLTCGFAE---AGKLLVV-PMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLN 71

  Fly    62 --------SYVKNPQAGAYPNYEELLIS-APGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDL- 116
                    ||....|     |.|.::.: |..:.|:.:..:|:      .:.|.|     ::||
Human    72 CTVKTYSTSYTLEDQ-----NREFMVFAHAQWKAQAQSIFSLL------MSSSSG-----FLDLF 120

  Fly   117 --HEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMP 179
              |      |..||   :..:.:|..:...:|.:..:.|:: |.|.:||..:||.:..:......
Human   121 FSH------CRSLF---NDRKLVEYLKESSFDAVFLDPFDT-CGLIVAKYFSLPSVVFTRGIFCH 175

  Fly   180 YYYDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYL---G 241
            :..:....|...:::.::.:||:..:.:.||:.|             |....::.|..:||   .
Human   176 HLEEGAQCPAPLSYVPNDLLGFSDAMTFKERVWN-------------HIVHLEDHLFCQYLFRNA 227

  Fly   242 VEVDVEEVARTQTAF-IFGNQHYSLMGS-------RPQSLQFVEIGGVHITKKAEQELPQNIANF 298
            :|:..|.:....||: ::.:....|:.:       :|.....:.|||::..:  .:.||.....:
Human   228 LEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQ--GKPLPMEFEAY 290

  Fly   299 LNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWA 362
            :|.|.| |::..|.||||  |.|.|.|..||.:.|...|..::|::.... |...|:..:.|||.
Human   291 INASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTR-PSNLANNTILVKWL 352

  Fly   363 PQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITV 427
            ||..||.||..:.|.:|.|..|..||:..|.|:::.|::|||..||..::.:|.|:.|:..::|.
Human   353 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS 417

  Fly   428 PNLKKAL-AELSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNG 491
            .:|:.|| |.::..||.:..:.:|.:..:|...||:.|::.||.|:.:.  .|..|:....:|..
Human   418 EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHK--GAPHLRPAAHDLTW 480

  Fly   492 FVYHSLDSVALILLPLILLILVLCYLC----------KRNPSKLAHK 528
            :.|||||.:. .||.::|.:..:.:.|          |:...|.|||
Human   481 YQYHSLDVIG-FLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	125/502 (25%)
		UDPGT	38..501	CDD:278624	122/500 (24%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	132/543 (24%)
		egt	<258..504	CDD:223071	78/253 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840