Protein Alignment Ugt36A1 and UGT2B28

DIOPT Version :10

• Sequence 1: NP_524686.3
• Gene: Ugt36A1 / 44058
• FlyBaseID: FBgn0015663
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 136/565 - (24%)
• Similarity: 257/565 - (45%)
• Gaps: 77/565 - (13%)

  Fly     7 SGVLIIVLLGILGIPEPISAGNILAVYPHFG-FSHFKVVMPILNELAHRGHDITVI----SYVKN 66
            :.||:::.||..     .|:|:...|....| :||:..:..||.||..|||::||:    |.:.:
Human     6 TSVLLLIHLGCY-----FSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFD 65

  Fly    67 PQAGAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVL---IREYVDL------------ 116
            |                 .|..:..:.:.| |..|.|....::   ::.:.|:
Human    66 P-----------------NDAFTLKLEVYP-TSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQE 112

  Fly   117 -------HEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLST 174
                   |:..:..|:.:.::..:.:.::..|   :|::..:.| ..|...||.|||:|.: .|.
Human   113 QEILWEFHDIFRNFCKDVVSNKKVMKKLQESR---FDIIFADAF-FPCGELLAALLNIPFV-YSL 172

  Fly   175 CALMPYYYDR----IDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNEL 235
            |....|..:|    :..|  |::|.......:.|:.:.||:.|.:......|.::....:..::.
Human   173 CFTPGYTIERHSGGLIFP--PSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQF 235

  Fly   236 VRKYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRP--QSLQFVEIGGVHITKKAEQELPQNIANF 298
            ..:.||....:.|.......::..|. :|.....|  .::.||  ||:|.  |..:.||:.:..|
Human   236 YSEVLGRPTTLFETMGKADIWLMRNS-WSFQFPHPFLPNIDFV--GGLHC--KPAKPLPKEMEEF 295

  Fly   299 LNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWA 362
            :..|.| ||:..|.||::  |::..::.:.|...|...|.|::|:::.:: ||.........||.
Human   296 VQSSGENGVVVFSLGSVI--SNMTAERANVIATALAKIPQKVLWRFDGNK-PDALGLNTRLYKWI 357

  Fly   363 PQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITV 427
            ||..||..||.:.|.:|||..|..|:::.|.|::..|::.||..|...::.:|..::||:..::.
Human   358 PQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSS 422

  Fly   428 PNLKKAL-AELSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNG 491
            .:|..|| ..::..||.:..:::|.:.:::...||..|::.:|.|:.:.  .|:.|:....:|..
Human   423 TDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHK--GAKHLRVAARDLTW 485

  Fly   492 FVYHSLDSVALILLPLILLILVLCYLCKRNPSKLAHKKVGKKPKR 536
            |.|||||.:..:|..:..:|.|:...|.....|.|.|  |||.||
Human   486 FQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARK--GKKGKR 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_524686.3	GT1_Gtf-like	28..469	CDD:340817	107/475 (23%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	126/537 (23%)