DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	156/554 - (28%)
Similarity:	263/554 - (47%)	Gaps:	63/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAY 72
            ||..:.|| :||:.......|||.::.....||..:.|.:...|...||::||:|.:| |:.
  Fly     3 GVHFVFLL-LLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLK-PKV--- 62

  Fly    73 PNYEEL-LISAPGEDQSSTTI-----------NLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCE 125
             .:::: ||..|.:::....:           |.:..|.:....|:.|:|....:|..:.:
  Fly    63 -THKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAELLSDPR---- 122

  Fly   126 HLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPII----GLSTCALMPYYYDRID 186
                       .:|.....:||::..||.:|.||.:|..|.:|:|    .....|:..|..:..:
  Fly   123 -----------FQRIYETKFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSE 176

  Fly   187 LPDTPAF--IQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGV--EVDVE 247
            |...|..  :.::.:||.      :|..|.:::.|.:|::...    |.:|.|.|..|  |.|:.
  Fly   177 LSYVPLMGTVATQPMGFL------KRTENALKSLLFEFIFVVF----DYKLTRIYNDVFPEQDMP 231

  Fly   248 EV--ARTQTAFIFGNQHYSLMGS-RPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFI 309
            .:  .|...:..|...|....|. ||.....:||||:.:..|.: .||::|..|::.:.:|.:|:
  Fly   232 TLKELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPD-PLPKDIDQFISNAKQGAVFL 295

  Fly   310 SWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVK 374
            |.||.|::|::..:.:..|.:||......:|||||..|....::|..|:..|.||..:|.||..|
  Fly   296 SLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTK 360

  Fly   375 LFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSK 439
            ||.:|.|..|.||:.:.|.|::..||:|||..||..::..|.||.||...||..:|:.||.|:.:
  Fly   361 LFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLE 425

  Fly   440 N-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALI 503
            | .|.|...:.|.::.:|..|..:|.::..|:::.:.  .|..||||.:.:|....::||..|
  Fly   426 NQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQ--GAPNLQSPSVHMNFIQLNNLDIYA-- 486

  Fly   504 LLPLILLILVLCYLCKRNPSKLAHKKVGKKPKRS 537
               ||:.||||..|..|..:|:...|.|.|.|.|
  Fly   487 ---LIVTILVLFVLLTRLVAKIVWNKFGGKAKIS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	133/490 (27%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	132/486 (27%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	134/497 (27%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	145/519 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454676
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	5.940