DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt37D1

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	149/550 - (27%)
Similarity:	257/550 - (46%)	Gaps:	42/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAY 72
            |.|::.||.:..:|:.....|||.|:.....|||.|.|.|:..||.:||::||:|.|  |....:
  Fly    14 GGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSV--PPKVTH 76

  Fly    73 PNYEELLISAPGEDQSSTTINLVPLTEHTPT---------RSLGVLIREYVDLHEEGQKTCEHLF 128
            .:...:::....||:......:..:.:..|:         .||.:||.:.||:.|:
  Fly    77 KSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLED--------- 132

  Fly   129 ASGHIERAIERHRNK--PYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTP 191
                 .|..|.:.||  .:|::...:|.:..|:||....|.|:|...:...|....:.:..|:..
  Fly   133 -----PRFQELYLNKGNKFDVVFVGFFFNTYQVALGARFNCPVIISWSGPPMMMVNEVLGNPELS 192

  Fly   192 AFIQSEFVGFAGQ-LNWHERLLNFVQA---KLLKFLYKYHSNRADNELVRKYLGVEVDVEEVART 252
            :..|.......|| :|:.:|:.||...   ..|.....:..|:..:.|..|...:....:  |:.
  Fly   193 SVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYNKFYDRLWSKDKSMPTFAQ--AKR 255

  Fly   253 QTAFIFGNQHYSLMGS-RPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFISWGSMVR 316
            ..:..|.|.|....|. ||.....:||||:.:..|.: .||::|..||.:...|.|..|.||.::
  Fly   256 NVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPD-PLPEDIQEFLEKGKHGAILFSLGSNLK 319

  Fly   317 ASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGG 381
            ...|..:.:..|.:.|.|...::|||||..:.....::..|:.||.||..:|.|||:|||.:|.|
  Fly   320 GEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAG 384

  Fly   382 LLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN-SYAQR 445
            ..|..|:.:.|.|:|..|::.||..||..:...|.||:|....:.|...|.|:.|:.:| .||:.
  Fly   385 KGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKT 449

  Fly   446 SLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLD--SVALILLPLI 508
            ....|:::.:|..:|.||.::..|:||.:.  .|..:|||.:.:|....::||  .:|.::|.::
  Fly   450 LKSFSQLYRDRPLSPQESVVYWTEYVIRHH--GAAHMQSPLVHMNFIASNNLDIYIIAALVLYIV 512

  Fly   509 LLI--LVLCYLCKRNPSKLAHKKVGKKPKR 536
            .:|  :|..::.::...|......|||.|:
  Fly   513 FIINKIVWKFVWRKLFGKSNKVSKGKKVKK 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	133/483 (28%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	131/481 (27%)
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	138/507 (27%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	135/505 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454683
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	5.940