DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt35E1

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	162/572 - (28%)
Similarity:	271/572 - (47%)	Gaps:	86/572 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVIS------Y 63
            |.||:..::   ||..|..:....|||::|....||:...:|.|..||..||:||.:|      .
  Fly     2 LASGLFYLI---ILLFPGFLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEP 63

  Fly    64 VKN------PQAGAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQK 122
            |||      |:  ...:::|||      .|.:|..|.....:.|         .|:|      ..
  Fly    64 VKNIYDIYVPE--VLNSFDELL------KQMTTPKNTWEFFDAT---------NEFV------YN 105

  Fly   123 TCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDL 187
            ..:.:|.:..:.|.|.|.....:||::.:.:..|...:||.....|||||:.|.:.....:.:..
  Fly   106 ITKDVFNNDGVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIGLAPCGIDWKIDEMVGN 170

  Fly   188 PDTPAFIQS------EFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDV 246
            |...:::||      ....|.|      |:.:.|:..:..|.:.:...:....|.:||.
  Fly   171 PSPMSYLQSPSSYLYNLDTFGG------RVAHVVEVAISWFNWHWRYEQKHEALYKKYF------ 223

  Fly   247 EEVARTQ--------TAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSA 303
            .::|.|:        .|.:..|||::|...||.....:|:||:||.:: .:.|.|::.:|:..|.
  Fly   224 PKIAETKPLSEISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQ-PKALAQDLEDFIQGSG 287

  Fly   304 E-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLAL 367
            | |||:.|.|:.||..::.:|:...::|...|.|.:::||:|.:|..|. .|..|..||.||..|
  Fly   288 EHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFEDEELQDI-PSNVLVRKWLPQQDL 351

  Fly   368 LCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKK 432
            |.|||||||.:|||:..|.||:|.|||:|..|.:.|||.|...::..|..|.|:|.|:|...||.
  Fly   352 LAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKA 416

  Fly   433 ALAELSKNSYAQRSLEVS-----KVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGF 492
            .:.:|    ..::..||:     ..:.::...|||:|:|...:|:.:.  .|..::..|.:|:.|
  Fly   417 TILQL----LTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHK--GAPHMRVAGRKLSFF 475

  Fly   493 VYHSLDSVALILLPLILLILVL--------CYLCKRNPSKLAHKKVGKKPKR 536
            .:||||.:..:||.::|:|:.:        |.:.|...::|..||..|:..|
  Fly   476 THHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTRLVVKKQRKQKVR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	141/498 (28%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	141/494 (29%)
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	140/500 (28%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	141/493 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454663
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.990