DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	155/543 - (28%)
Similarity:	260/543 - (47%)	Gaps:	76/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVLIIVLLGIL--GIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYV---KNP 67
            |:|:|.|:.:.  ...|.:.:..||||:|..|.|.:......:.|||||||::|||:..   ||.
  Fly    11 GILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNE 75

  Fly    68 QAGAYPNY--------EELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTC 124
                 ||:        .|::.:....|.:.|......||  ..|:.|.:|....:|     ....
  Fly    76 -----PNFRVIGAKKIHEIMAAFGNADYTQTASQWQMLT--MTTQFLNLLTTSILD-----DAAV 128

  Fly   125 EHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCA-----------LM 178
            :.|..||           :.:||::.|...::....|.:......||:|:..           :.
  Fly   129 KDLLNSG-----------EKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNIS 182

  Fly   179 PYYYDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLL---KFLYKYHSNRADNELVRKYL 240
            |..|:       |..:.|.    ..|:::.:|::|..:|.::   |.:....|.|   :|..||.
  Fly   183 PLSYN-------PLLLSSR----TEQMDFKDRVMNVFEASVMWLHKRIVHLPSQR---DLYAKYF 233

  Fly   241 -GVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAE-QELPQNIANFLNQSA 303
             .....::||..:....:.| ||:||...||.....:|:||:|:.:|.: |.|.:.::.|:.||.
  Fly   234 PTARKSLDEVLDSFALMLLG-QHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSE 297

  Fly   304 EGVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALL 368
            :|||:.|.||.:::..:.......:::...|.|.:::||:|.|:.|:...:.|: .||.||..:|
  Fly   298 KGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKPDNVFI-SKWFPQPDIL 361

  Fly   369 CHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKA 433
            .||.||||.:|||||.|.||::.|||:|..||:.||.||....:..|.||..|...:....|...
  Fly   362 AHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPL 426

  Fly   434 LAELSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSL 497
            :.||..| |||..:...||:|.::::|.||.|||..|:|:.:.  .|:.|:....:|:...:|.|
  Fly   427 IQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHK--GAKHLRCASRDLDFIQFHGL 489

  Fly   498 DSVALILL-----PLILLILVLC 515
            |:..|::.     .||::||:.|
  Fly   490 DTWGLLIAITFVSLLIVVILIKC 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	143/496 (29%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	138/490 (28%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	140/495 (28%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	143/499 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454666
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.990