DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	140/566 - (24%)
Similarity:	252/566 - (44%)	Gaps:	71/566 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIIVLLGIL--GIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHR--GHDITVISYVKNPQA- 69
            ::.|.||.|  ||   :...|:|.|:|....||:.....:|.||...  .|.:|:||    |.|
  Fly     3 ILQVFLGTLLCGI---VLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLIS----PHAA 60

  Fly    70 -----GAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHLFA 129
                 ...|...||.|....|:.....::.    |....|:..|:.| :..|...|....:.|.:
  Fly    61 QEGVDAEIPKIRELRIEGLRENWLDMGMSF----EAEEMRAQSVMER-FTRLIYAGTTNVDILLS 120

  Fly   130 SGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTPAFI 194
            ...:.:.:.  ..:.:|||:.:.|.||..|.||....:|.:.:|......:..:....|.:.:..
  Fly   121 DPQVRKLLT--SGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLD 183

  Fly   195 QSEFVGFAGQLNWHERLLNFVQAKLLKFLYKY---------HSNRADNELVRKYLGVEVDVEEVA 250
            .|.|:.|..::|..:|:||.:.:...:..|.:         ::|..  ||:.|.|.:..|:.:
  Fly   184 PSNFLPFTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHF--ELLVKELPLYRDLTK-- 244

  Fly   251 RTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFISWGSMV 315
            ....|.|  |.|..|...|......||:||:|::...:..||:::.:|:..:..|||:.|.|:.|
  Fly   245 NLSLALI--NSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFMESAPSGVIYFSLGADV 307

  Fly   316 RASSIDEDKLSAILEV---LKSQPLKIIWKWEADE------TPDTDASKFLFVKWAPQLALLCHP 371
            ..:.:.::||:.||:|   ||.  ...:.|||.:|      .|:    ..:...|.||.|:|.||
  Fly   308 ETAQLPQEKLAIILDVFGHLKE--FHFLLKWEKEEFTAEQVLPE----NVMIADWWPQQAILHHP 366

  Fly   372 KVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAE 436
            :||:|.|..|.|...||:...||:|..||..:|.:.|..:|..|:.:.:.|..:...:|...:.:
  Fly   367 QVKMFISSCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQ 431

  Fly   437 LSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSV 500
            |:.| ||.::..::.:....|..||:..|:..::.::.:|  .|..|:|....||.:....:|.:
  Fly   432 LTLNTSYVEKLGQLKERLISRDSTPVGKAVRKIQLILESG--GADFLKSHANTLNFWRAEGVDVL 494

  Fly   501 ALILLP----LILLILVLCYLCKRN----------PSKLAHKKVGK 532
            .:|.:.    |.:..|.:|::.:::          |.:...|.||:
  Fly   495 LIIAVGFFGILTIPFLAICFILRKSYHSQAAQDQPPYRTNLKVVGR 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	125/493 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	122/489 (25%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	129/504 (26%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	109/431 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454675
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	5.940