DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	141/555 - (25%)
Similarity:	252/555 - (45%)	Gaps:	71/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGA 71
            ||:|:  ||..|    |.:.|..:.|:|..| ||:..:..::.||..|||...|::
  Rat    11 SGLLL--LLCAL----PWAEGGKVLVFPMEG-SHWLSMRDVVRELHARGHQAVVLA--------- 59

  Fly    72 YPNYEELLISAPGEDQSSTTINLVPLTEHTPTR--------------SLGVLIREYVDLHEEGQ- 121
                .|:.:....||..:.....||.|:.....              ||.::::....::....
  Rat    60 ----PEVTVHIKEEDFFTLQTYPVPYTKEEYRHHLLGHLQNFFETEFSLKLVLQRMAAVNNVSTF 120

  Fly   122 --KTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDR 184
              ::|..|.   |....|:...:..:|::||:.| ..|...||..|.:|.:......|....::.
  Rat   121 YVRSCRGLL---HNTALIQSLNSSSFDVVLTDPF-FPCGAVLAMYLRVPAVFFLQSMLCELEFEA 181

  Fly   185 IDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSN-----RADNELVRKYLGVEV 244
            .:.|:..::|.......:..:::.:|:.|.:..  :.::|..|.|     |..::|:::    ||
  Rat   182 TNSPNPSSYIPRLLTLNSDHMSFLDRVKNMLYP--VPWMYLCHVNYGSLARLASDLLQR----EV 240

  Fly   245 DVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIF 308
            .|.|:.|..:.::. .:.:.....||.....|.|||::...:  :.|.|....::|.|.| |::.
  Rat   241 SVVEILRHASVWLL-RKDFVFYYPRPFMPNMVFIGGINCANR--KPLSQEFEAYVNASGEHGIVV 302

  Fly   309 ISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKV 373
            .|.||||  |.|.|.|...|.|.|...|..::|::.... |...|...:.|||.||..||.|||.
  Rat   303 FSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTR-PSNLAKNTILVKWLPQNDLLGHPKA 364

  Fly   374 KLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELS 438
            :.|.:|.|..|..|.:..|.|:::.|::|||..||..::.||.|:.|:..::|..:|:.||..:.
  Rat   365 RAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVI 429

  Fly   439 KN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVAL 502
            .| ||.:..:.:|.:..:|...||:.|::.||:|:.:.  .|..|:....:|..:.|||||.:..
  Rat   430 NNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHK--GAPHLRPAAHDLTWYQYHSLDVIGF 492

  Fly   503 IL---LPLILLILVLC-YLCK-----RNPSKLAHK 528
            :|   |.::.::...| |.|:     :...|.:||
  Rat   493 LLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	124/490 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	122/486 (25%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	130/527 (25%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	87/288 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910