DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt301D1

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	148/543 - (27%)
Similarity:	251/543 - (46%)	Gaps:	65/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIIVLLGILGIPEPISAGN-ILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYP 73
            ::|.|:|:|    ...||: ||.:.|....||:..:....|:|..:||.:|.::  .:|....:.
  Fly    11 MLIFLIGLL----EFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVN--NHPTKHPHE 69

  Fly    74 NYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVL--IREYVDLH---EEGQKTCEHLFASGHI 133
            |..|::|| |..|          :.:|.|..::..:  :.::.:|.   ..|..|.||.|....:
  Fly    70 NLTEIIIS-PSFD----------IPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKV 123

  Fly   134 ERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPD---TP-AFI 194
            ::.|| .::..|||::.|.|..:..|...|..|.|::.:.|..    |.|.||...   || :.|
  Fly   124 KKLIE-SKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMG----YADNIDHAMGILTPWSLI 183

  Fly   195 QSEFVGFAGQLNWHERLLNFVQA-------------KLLKFLYKYHSNRADNELVRKYLGVEVDV 246
            ....:....::.:.:|..|...:             |:.|...||.....:..|..     .:|:
  Fly   184 PHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPN-----VLDL 243

  Fly   247 EEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFISW 311
            |.    ..:.:..|.|.|:...||.....:::||.||.|  .::||.::.|||:.:..|||:.|.
  Fly   244 ER----NISLVLINAHRSIDLPRPSMPGLIDVGGAHIQK--PKQLPTDLQNFLDNATYGVIYFSM 302

  Fly   312 GSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLF 376
            ||.|:::.:.::|.:.||:.......::|||:|.|...|. .|..:..||.||..:|.||.||||
  Fly   303 GSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDL-PSNVMIKKWMPQNDILAHPNVKLF 366

  Fly   377 WSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN- 440
            .:|||:.||.|.::.|.|:|..|:||||..|.......|....|.:..:|..:|.:.:..|..:
  Fly   367 ITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDP 431

  Fly   441 SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALILL 505
            .|.:.:||||:.|.:....||:.|.:.:|::|.:.  .||.|:|.|..:....|..||.:..:||
  Fly   432 QYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHR--GARHLKSHGAFIPLHQYLLLDVLGCLLL 494

  Fly   506 PLILLILVLCYLCKRNPSKLAHK 528
            ...|.|.:...:.:|     .||
  Fly   495 GAFLAIWLPWRMIRR-----VHK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	133/488 (27%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	132/485 (27%)
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	138/506 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	129/477 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	6.060