DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	140/530 - (26%)
Similarity:	239/530 - (45%)	Gaps:	55/530 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYPNY--EELLISAPGEDQS 88
            ||.:|.| |..| ||:..:..|:.:|:||||::.|:....:...|...|:  :...:|...||.:
  Rat    25 AGRLLVV-PMDG-SHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMGKSLNFTVKTYSVSYTLEDLN 87

  Fly    89 ------------STTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHLFASGHIERAIERHR 141
                        :..:.:..|.:|:     |....|.:..|      |..||..   ::.:|..:
  Rat    88 YHFKFFAHNQWKTQEVGMFSLLKHS-----GKGFFELLFSH------CRSLFKD---KKLVEYLK 138

  Fly   142 NKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTPAFIQSEFVGFAGQLN 206
            ...:|.:..:.|:. |.|.|||..:||.:..|......|..:....|..|:::......|...:.
  Rat   139 QSSFDAVFLDPFDV-CGLILAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPSYVPRILSKFTDTMT 202

  Fly   207 WHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQ 271
            :.||:.|.:.....:....|....| .|:..:.|...|.:.::....:.::| ...:.|...||.
  Rat   203 FKERVWNHLSYMKERAFCPYFFKTA-VEIASEVLQTPVTMRDLFSPVSIWMF-RTDFVLEFPRPV 265

  Fly   272 SLQFVEIGGV--HITKKAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLK 333
            ....|.|||:  |..|...:|...    ::|.|.| |::..|.||||  |.|.|.|...|.|.|.
  Rat   266 MPNMVYIGGINCHQGKPLSKEFEA----YVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALG 324

  Fly   334 SQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVT 398
            ..|..::|::.... |...|...:.|||.||..||.|||.:.|.:|.|..|..|.:..|.|:::.
  Rat   325 RIPQTVLWRYTGTR-PSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMM 388

  Fly   399 PIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN-SYAQRSLEVSKVFNERQQTPLE 462
            |::|||..||..::.||.|:.|:..::|..:|:.||..:..| ||.:..:.:|.:..:|...||:
  Rat   389 PLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLD 453

  Fly   463 SAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALIL---LPLILLILVLC-YLCK---- 519
            .|::.||:|:.:.  .|..|:....:|..:.|||||.:..:|   |.::.::...| |.|:
  Rat   454 LAVFWVEYVMRHK--GAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFG 516

  Fly   520 -RNPSKLAHK 528
             :...|.:||
  Rat   517 GKGRVKKSHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	124/466 (27%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	126/480 (26%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	136/522 (26%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	81/249 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910