DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	135/525 - (25%)
Similarity:	248/525 - (47%)	Gaps:	53/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SHFKVVMPILNELAHRGHDITVISY--VKNPQAGAYP----NYEELLISAPGEDQSSTTINLVPL 97
            ||:..:..||.|||.|||::||:.|  :...|:...|    |...|..:...|:..:..:||.
  Rat    34 SHWLNLKTILEELAARGHEVTVLKYPSIIIDQSKLTPLQFENIPVLYETEVAENHLNEIVNLA-- 96

  Fly    98 TEHTPTRSLGVLIREYVDLHEEGQKTCEHLFASG-HIERAIERHRNKPYDLLLTEYFNSDCQLAL 161
            ....|..||....|...|...:.....|.|..|. :.:..:.:.|:..||:::.:.. ..|...:
  Rat    97 VNVIPNLSLWEAARTLQDFFLQLTGNFEDLCRSTLYNQTLMNKLRDAKYDVMVLDPV-IPCGELV 160

  Fly   162 AKLLNLPII-------GLST---CALMPYYYDRIDLPDTPAFIQSEFVGFAGQLNWH----ERLL 212
            |::|.:|.:       |.|.   |..:|     :.|...|..:        |:|..|    ||:.
  Rat   161 AEVLQIPFVNTLRFSMGYSMEKYCGQLP-----VPLSYVPVVM--------GELTDHMTFTERVK 212

  Fly   213 NFVQAKLLKFLYKYHSNRADNELVRKYLGVEVD-VEEVARTQTAFIFGNQHYSLMGSRPQSLQFV 276
            |.:.:...:|..:.:.....::...|.||.... .:.|.:.:...|  ..::.:...||....|.
  Rat   213 NMMLSLFFEFWLQQYDFAFWDQFYSKTLGRPTTFCKTVGKAEIWLI--RTYWDIEFPRPYLPNFE 275

  Fly   277 EIGGVHITKKAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKII 340
            .:||:|.  |..:.||:.:..|:..|.| ||:..|.|||::  ::.|:|.:.|...|...|.|::
  Rat   276 FVGGLHC--KPAKPLPKELEEFVQSSGEHGVVVFSLGSMIK--NLTEEKANLIASALAQIPQKVL 336

  Fly   341 WKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQF 405
            |:: :.:.|.|.......:.|.||..||.|||.:.|.:|||..|..|:::.|.|::..|::|||.
  Rat   337 WRY-SGKKPATLGPNTRILNWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGVPMVGIPMFGDQP 400

  Fly   406 LNAFSVQNRGMGLKLDYQDITVPNLKKAL-AELSKNSYAQRSLEVSKVFNERQQTPLESAIWSVE 469
            .|...::.:|..:|:....:|..:|..|| |.:::.||.:.::.:|:|.:::...||:.|::.:|
  Rat   401 YNIAHMEAKGAAVKVAINTMTSADLLSALRAVINEPSYKENAMRLSRVHHDQPVKPLDRAVFWIE 465

  Fly   470 HVISNGLIAARLLQSPGIELNGFVYHSLDSVALILLPLILLILVL--C--YLCKRNPSKLAHKKV 530
            .|:.:.  .|:.|:....:|:.|.|||||.:..:|:.::.|..|:  |  ::|::...:...||.
  Rat   466 FVMRHK--GAKHLRVAAHDLSWFQYHSLDVIGFLLVCVVTLTFVITKCSLFMCRKCCLRERKKKG 528

  Fly   531 GKKPK 535
            .:|.|
  Rat   529 NRKKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	117/459 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	126/485 (26%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	131/509 (26%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	75/244 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840