DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt2b7

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_775445.2	Gene:	Ugt2b7 / 286989	RGDID:	708417	Length:	529	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	141/553 - (25%)
Similarity:	262/553 - (47%)	Gaps:	69/553 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CLRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI----SYV 64
            |.|||                :.|.:| |:| ..:||:..:..||:||..|||::||:    |..
  Rat    17 CFRSG----------------NCGKVL-VWP-LEYSHWMNLKIILDELVQRGHEVTVLRPSSSVF 63

  Fly    65 KNPQAGAYPNYEELLISAPGEDQS-------STTINLVPLTEHTPTR---SLGVLIREYVDLHEE 119
            .:|:..:...||....::..::..       :|....||  ::|..|   ||..:..::.||
  Rat    64 LDPKKASGLVYETFPTTSNNDEVEKFFTQWVNTWTYDVP--KYTCLRYYPSLNKMFGQFSDL--- 123

  Fly   120 GQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPII-----GLSTCALMP 179
            ..:.|..:.::.|:   :.:.:...:|::|::.. ..|...:|::|.||.:     |:.
  Rat   124 WLQLCREVVSNKHL---MAKLKESQFDVVLSDAV-GPCGELIAEILQLPFVYSLRFGIG------ 178

  Fly   180 YYYDRIDL--PDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGV 242
            |..::...  |..|:::.....|.:||:.:.||:.|.:......|.::....:..:....:.||.
  Rat   179 YGIEKYSAGQPFPPSYVPIILSGLSGQMTFMERVENMLCLLYFDFWFESFPAKDWDPFFSEILGR 243

  Fly   243 EVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVE-IGGVHITKKAEQELPQNIANFLNQSAE-G 305
            ...:.:..:....::. ..::.|...|| ||..:| :||:|.  :..:.||:.:.:|...|.| |
  Rat   244 PTTMVDTMKKAEIWLI-RSYWDLEFPRP-SLPNIEFVGGLHC--QPAKPLPKEMEDFAQSSGEHG 304

  Fly   306 VIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCH 370
            |:..|.|||:|  :|.:::.:.|...|...|.|:.|::|. :.|||........||.||..||.|
  Rat   305 VVVFSLGSMIR--NITQERANTIASALAQIPQKVFWRFEG-KKPDTLGPNTRVFKWIPQNDLLGH 366

  Fly   371 PKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKAL- 434
            ||.|.|.:|||..|..||:|.|.|::..|::.:|..|...:..:|..:.||:..::..:|..||
  Rat   367 PKTKAFVTHGGANGIYESIHHGIPMVGIPLFAEQRDNVAHMVAKGAAVSLDFHTMSSSDLLNALK 431

  Fly   435 AELSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDS 499
            |.::|.||.::.:.:|.:.:::...||:.|::.:|.|:.:.  .|:.|:.....|..:.|||||.
  Rat   432 AVINKPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHK--GAKHLRPLAHNLAWYQYHSLDV 494

  Fly   500 VALIL---LPLILLILVLCYLCKRNPSKLAHKK 529
            :..:|   |.::||.:..|....|...|:|..|
  Rat   495 IGFLLACVLAIVLLAVKCCLFLYRFFVKVAKNK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	121/490 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	124/486 (26%)
Ugt2b7	NP_775445.2	UDPGT	24..527	CDD:278624	136/528 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910