DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	138/542 - (25%)
Similarity:	263/542 - (48%)	Gaps:	45/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI----SYVKNPQAGA 71
            :.:|:.::....|.:.|.:| |:| ..:||:..:..||||||.|||::||:    |.:..|...:
  Rat     8 VFLLIQLICYFRPGACGKVL-VWP-TEYSHWINIKIILNELAQRGHEVTVLVSSASILIEPTKES 70

  Fly    72 YPNYEELLISAPGEDQSST--------TINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHLF 128
            ..|:|...:.....|...:        |.:...|:..|....:..:..||.|:.|   ..|:.|.
  Rat    71 SINFEIYSVPLSKSDLEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYSDVVE---NLCKALI 132

  Fly   129 ASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPII-GLSTCALMPYYYDRID-----L 187
            .:..:.:.::   ...:|::|.:.. ..|...||:||..|:: .|..|   |.|  |.:     |
  Rat   133 WNKSLMKKLQ---GSQFDVILADAV-GPCGELLAELLKTPLVYSLRFC---PGY--RCEKFSGGL 188

  Fly   188 PDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEEVART 252
            |..|:::.......:.::.:.||:.|.:|.....|.::....::.::.....||....:.|:...
  Rat   189 PLPPSYVPVVLSELSDRMTFVERVKNMLQMLYFDFWFQPFKEKSWSQFYSDVLGRPTTLTEMMGK 253

  Fly   253 QTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFISWGSMVR 316
            ...::. ...:.|....|....|..:||:|.  |..:.||:.:..|:..|.| ||:..|.||||:
  Rat   254 ADIWLI-RTFWDLEFPHPFLPNFDFVGGLHC--KPAKPLPREMEEFVQSSGEHGVVVFSLGSMVK 315

  Fly   317 ASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGG 381
              ::.|:|.:.:...|...|.|::|:::. :.|||..|.....||.||..||.|||.|.|.:|||
  Rat   316 --NLTEEKANVVASALAQIPQKVVWRFDG-KKPDTLGSNTRLYKWIPQNDLLGHPKTKAFVAHGG 377

  Fly   382 LLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKAL-AELSKNSYAQR 445
            ..|..|:::.|.|::..|::.||..|...:..:|..:::|:..::...|..|| ..::..||.:.
  Rat   378 TNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSYKEN 442

  Fly   446 SLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALILLPLILL 510
            ::.:|::.:::...||:.|::.:|:|:.:.  .|:.|:|...:|:.|.|||||.:..:||.::.:
  Rat   443 AMRLSRIHHDQPVKPLDRAVFWIEYVMRHK--GAKHLRSTLHDLSWFQYHSLDVIGFLLLCVVGV 505

  Fly   511 ILVL---CYLCKRNPSKLAHKK 529
            :.::   |..|.|..:.:..||
  Rat   506 VFIITKFCLFCCRKTANMGKKK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	121/483 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	125/482 (26%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	134/524 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910