DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	134/535 - (25%)
Similarity:	252/535 - (47%)	Gaps:	52/535 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTCLRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVIS--- 62
            ::.|.:||                :.|.:| |:| ..|||:..:..||:||..|||::||:.
  Rat    14 ISCCFQSG----------------NCGKVL-VWP-MEFSHWMNIKTILDELVQRGHEVTVLKPSA 60

  Fly    63 -YVKNPQAGAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTR----SLGVLIREYVD-LHEEGQ 121
             ||.:|:......:|....|...::..:..|.||.:..:...|    |...|::..:| ..:...
  Rat    61 YYVLDPKKSPDLKFETFPTSVSKDELENYFIKLVDVWTYELQRDTCLSYSPLLQNMIDGFSDYYL 125

  Fly   122 KTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYY----- 181
            ..|:...::..:...::..:   :|:||::.. :.|...:|::|::|.  |.:....|.|
  Rat   126 SLCKDTVSNKQLMAKLQESK---FDVLLSDPV-AACGELIAEVLHIPF--LYSLRFSPGYKIEKS 184

  Fly   182 YDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDV 246
            ..|..||  |:::.....|..|.:.:.:|:.|.:......|.:...:.:..:....:.||....:
  Rat   185 SGRFILP--PSYVPVILSGMGGPMTFIDRVKNMICTLYFDFWFHMFNAKKWDPFYSEILGRPTTL 247

  Fly   247 EEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFIS 310
            .|.......::. ..::.|....|.......|||:..  :..:.||:::.:|:..|.| ||:..|
  Rat   248 AETMGKAEMWLI-RSYWDLEFPHPTLPNVDYIGGLQC--RPPKPLPKDMEDFVQSSGEHGVVVFS 309

  Fly   311 WGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKL 375
            .||||  ||:.|:|.:||...|...|.|::||::. :||.|........||.||..||.|||.|.
  Rat   310 LGSMV--SSMTEEKANAIAWALAQIPQKVLWKFDG-KTPATLGPNTRVYKWLPQNDLLGHPKTKA 371

  Fly   376 FWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN 440
            |.:|||..|..|:::.|.|::..|::|:|..|...:..:|..:.|:.:.::..:|..||.|:..|
  Rat   372 FVTHGGANGVYEAIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINN 436

  Fly   441 S-YAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALIL 504
            . |.:.::.:|.:.:::...||:.|::.:|.|:.:.  .|:.|:..|..|..:.|||||.:..:|
  Rat   437 PFYKKNAVWLSTIHHDQPMKPLDKAVFWIEFVMRHK--GAKHLRPLGHNLPWYQYHSLDVIGFLL 499

  Fly   505 L--PLILLILVLCYL 517
            .  .:|.::.|..:|
  Rat   500 TCSAVIAVLTVKSFL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	119/482 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	123/478 (26%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	131/509 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840