DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	132/535 - (24%)
Similarity:	248/535 - (46%)	Gaps:	58/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CLRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVIS----YV 64
            |.:||                ..|.:| |:| ..|||:..:..||:||..|||::||:.    :.
  Rat    17 CFKSG----------------HCGKVL-VWP-MDFSHWMNIKIILDELVQRGHEVTVLKPSAYFF 63

  Fly    65 KNPQAGAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRS--------LGVLIREYVDLHEEGQ 121
            .:|:..:...:|....|...::..:..|.|:.:..:...|.        |..|:.|:...:   .
  Rat    64 LDPKKSSDLKFEIFSTSISKDELQNHFIKLLDVWTYELPRDTCLSYSPILQNLVYEFSYFY---L 125

  Fly   122 KTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYY----- 181
            ..|:...::..:...::..:   :|:|..:...| |...:|:||::|.  |.:.:..|.:
  Rat   126 SICKDAVSNKQLMTKLQESK---FDVLFADPVAS-CGDLIAELLHIPF--LYSLSFSPGHKLEKS 184

  Fly   182 YDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDV 246
            ..:..||  |:::.....|.||::.:.:|:.|.:......|.::...::..:....:.||....|
  Rat   185 IGKFILP--PSYVPVILSGLAGKMTFIDRVKNMICMLYFDFWFEILRHKEWDTFYSEILGRPTTV 247

  Fly   247 EEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFIS 310
            :|.......::. ..::.|....|.......|||:|.  |..:.||:::..|:..|.| ||:..|
  Rat   248 DETMSKVEIWLI-RSYWDLKFPHPTLPNVDYIGGLHC--KPAKPLPKDMEEFVQSSGEHGVVVFS 309

  Fly   311 WGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKL 375
            .||||  |::.|:|.:||...|...|.|::||::. :||.|........||.||..:|.|||.|.
  Rat   310 LGSMV--SNMTEEKANAIAWALAQIPQKVLWKFDG-KTPATLGPNTRVYKWLPQNDILGHPKTKA 371

  Fly   376 FWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN 440
            |.:|||..|..|:::.|.|::..|::|||..|...:..:|..:.|:.:.::..:...||.|:..|
  Rat   372 FVTHGGANGLYEAIYHGIPMIGIPLFGDQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDN 436

  Fly   441 S-YAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALIL 504
            . |.:..:.:|.:.:::...||:.|::.:|.::.:.  .|:.|:..|..|..:.|||||.:..:|
  Rat   437 PFYKKNVMLLSTIHHDQPMKPLDRAVFWIEFIMRHK--GAKHLRPLGHNLPWYQYHSLDVIGFLL 499

  Fly   505 --LPLILLILVLCYL 517
              ..:|..:.|.|.|
  Rat   500 TCFAVIAALTVKCLL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	116/485 (24%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	120/481 (25%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	129/512 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910