DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	155/579 - (26%)
Similarity:	267/579 - (46%)	Gaps:	99/579 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTCLRSG----VLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI 61
            |:...||.    :|..:||.:|| |....||.:| |.|..| ||:..::.::.:|..:||::.||
  Rat     1 MSVVCRSSCSLLLLPCLLLCVLG-PSASHAGKLL-VIPIDG-SHWLSMLGVIQQLQQKGHEVVVI 62

  Fly    62 SYVKNPQA------GAYPNYEELLISAPGEDQSSTTINL-------------VPLTEHTPTRSLG 107
            :    |:|      |::....:..:....|:.::..:.|             |..|.:...|...
  Rat    63 A----PEASIHIKEGSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSS 123

  Fly   108 VLIREYVDLHEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGL 172
            :|:           ..|.||..:.....::|:..   :|.|||:.| ..|...:|:.|:||.:
  Rat   124 MLL-----------SGCSHLLHNAEFMASLEQSH---FDALLTDPF-LPCGSIVAQYLSLPAV-- 171

  Fly   173 STCALMPYYYD----RIDLPDT--PA---FIQSEFVGFAGQLNWHERLLNFVQAKLLKFL----Y 224
                   |:.:    .:||..|  ||   ::.........::|:.:|:.|.:.|....||    |
  Rat   172 -------YFLNALPCSLDLEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVY 229

  Fly   225 KYHSNRADNELVRKYLGVEVDVEEVARTQTAFIFGN---QHYSLMGSRPQSLQFVEIGGVH-ITK 285
            ..:.:.| .|:::|    ||.|:::....:.::..|   :.|    .||.....|.|||:: :.|
  Rat   230 SPYGSLA-TEILQK----EVTVKDLLSPASIWLMRNDFVKDY----PRPIMPNMVFIGGINCLQK 285

  Fly   286 KAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETP 349
            ||   |.|....::|.|.| |::..|.||||  |.|.|.|...|.|.|...|..::|::.... |
  Rat   286 KA---LSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTR-P 344

  Fly   350 DTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNR 414
            ...|...:.|||.||..||.|||.:.|.:|.|..|..|.:..|.|:::.|::|||..||..::.|
  Rat   345 SNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETR 409

  Fly   415 GMGLKLDYQDITVPNLKKALAELSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIA 478
            |.|:.|:..::|..:|:.||..:..| ||.:..:.:|.:..:|...||:.|::.||:|:.:.  .
  Rat   410 GAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHK--G 472

  Fly   479 ARLLQSPGIELNGFVYHSLDSVALIL---LPLILLILVLC-YLCK-----RNPSKLAHK 528
            |..|:....:|..:.|||||.:..:|   |.::.::...| |.|:     :...|.:||
  Rat   473 APHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	136/508 (27%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	132/500 (26%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	142/542 (26%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	84/257 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910