DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_659094.1	Gene:	Ugt3a2 / 223337	MGIID:	2145969	Length:	523	Species:	Mus musculus

Alignment Length:	555	Identity:	130/555 - (23%)
Similarity:	238/555 - (42%)	Gaps:	91/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQA 69
            |.|.:.:.|:|        :.|..||.: .....||:.|:..:...|...||::|.:.|    ::
Mouse     9 LMSFLFLEVIL--------LEAAKILTI-STLSASHYIVISRVSQVLHEGGHNVTKLLY----ES 60

  Fly    70 GAYPNYE------ELLISAPGEDQSSTTINL-VPLTE---------HTPTRSLGVLIREYVDLHE 118
            ...|::.      :::...|.|||.....:| ..|||         ||           .:.:|:
Mouse    61 ANIPDFRKEKPSYQVINWRPPEDQEKKFADLRHRLTEEITYGRSKHHT-----------LLKIHQ 114

  Fly   119 EGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYD 183
            .....|..|.:...|   ::..:|:.:||:|.:      .:.|..||.:..:|....:.:|:.:.
Mouse   115 YFGDLCSQLLSRKDI---MDFLKNENFDLVLLD------SMDLCSLLIVEKLGKRFVSFLPFQFS 170

  Fly   184 RID--LPDTP-AFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHS--NRADNELVRKYLGVE 243
            .:|  ||..| ::......|...|:::..|:.||:.  .|.|..|...  ::.|:.:...::...
Mouse   171 YMDFGLPSAPLSYAPVYGSGLTDQMDFWGRVKNFLM--FLDFSMKQREILSQYDSTIQEHFVEGS 233

  Fly   244 VDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVI 307
            ..|......:....|.|..::|..:||.....|.:||  :..|..|.:||::.||::|..: |.:
Mouse   234 QPVLSDLLLKAELWFVNSDFALDFARPLFPNTVYVGG--LLDKPVQPIPQDLENFISQFGDSGFV 296

  Fly   308 FISWG---SMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVK---WAPQLA 366
            .::.|   ||:::..|.::..||...:    |..::|..:....| .|.|....||   |.||..
Mouse   297 LVALGSIVSMIQSKEIIKEMNSAFAHL----PQGVLWTCKTSHWP-KDVSLAPNVKIMDWLPQTD 356

  Fly   367 LLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLK 431
            ||.||.::||.:|||:....|:||.|.|::..|.:.||..|...|:.:.:|:.:..|.:...:..
Mouse   357 LLAHPSIRLFVTHGGMNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKNLGVSIQLQTLKAESFA 421

  Fly   432 KALAELSKNSYAQRSLEVSKVF-NERQQTPLESAIWSVEHVISNGLIAARL----LQSPGIELNG 491
            ..:.::.::...:.:...||:. :....||.:..:..::|::..| .||.|    .|.|..|
Mouse   422 LTMKKIIEDKRYKSAAMASKIIRHSHPLTPAQRLLGWIDHILQTG-GAAHLKPYAFQQPWHE--- 482

  Fly   492 FVYHSLDSVALILLPLIL---------LILVLCYL 517
              .:.|| |.|.||.|:|         |:.|..||
Mouse   483 --QYMLD-VFLFLLGLMLGTLWLSVKVLVAVTRYL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	109/495 (22%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	113/495 (23%)
Ugt3a2	NP_659094.1	UDPGT	23..488	CDD:278624	115/505 (23%)
Ugt3a2	NP_659094.1	egt	<235..488	CDD:223071	68/266 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840170
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850