DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	536	Identity:	130/536 - (24%)
Similarity:	252/536 - (47%)	Gaps:	58/536 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYPNYE 76
            ::|...:||..   |..|:.|.|....||..:...:.:.|..|||. ||:...:........:|.
Mouse     9 MLLWSAVGIAR---AAKIIIVPPIMFESHLYIFKTLASALHERGHH-TVLLLSEGRDIAPSNHYS 69

  Fly    77 ELLISAPGEDQSSTTINLVPLTEHTPTRSL--GVLIR-EYVDLHEEGQKTCEHLFASGHIERAIE 138
              |...||...|:|:...:    .:..|::  |.|.. |.||:.:...|.|:.:..:   :..|:
Mouse    70 --LQRYPGIFNSTTSDAFL----QSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGN---QALIQ 125

  Fly   139 RHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTPAFIQSEFVGFAG 203
            ..:.:.:||||.:. |..|...:|.||.:.....||..   :|...:..|...|::.........
Mouse   126 GLKKEKFDLLLVDP-NDMCGFVIAHLLGVKYAVFSTGL---WYPAEVGAPAPLAYVPEFNSLLTD 186

  Fly   204 QLNWHERLLN---FVQAKL-LKFLY--KYHSNRADNELVRKYLGVEVDVEEVARTQTAFIFGNQH 262
            ::|:.||:.|   ::.::: :.||.  ||      ..:::||..:.      |::....:.|:..
Mouse   187 RMNFLERMKNTGVYLISRIGVSFLVLPKY------ERIMQKYNLLP------AKSMYDLVHGSSL 239

  Fly   263 YSLMGS------RPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSI 320
            :.|...      ||.....|.:||: :||.| ..||:::..:::.:.| |.:.:|:|:.|:  .:
Mouse   240 WMLCTDVALEFPRPTLPNVVYVGGI-LTKPA-SPLPEDLQRWVSGAQEHGFVLVSFGAGVK--YL 300

  Fly   321 DEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGT 385
            .||..:.:...|...|.|:||::...: |....:....::|.||..||.|..::.|.|||||...
Mouse   301 SEDIANKLAGALGRLPQKVIWRFSGTK-PKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSI 364

  Fly   386 TESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN-SYAQRSLEV 449
            .|:::.|.|::..|::||.:.....||.:|||:.|::..:|...|..||.::..| ||.||:.::
Mouse   365 FETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKL 429

  Fly   450 SKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALILLPLILLILVL 514
            |::..::...|:....:.:::::.:.  .||.|:|...:::...|..||...::||..:||..:|
Mouse   430 SEIHKDQPGHPVNRTTYWIDYILRHD--GARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFIL 492

  Fly   515 CYLCKRNPSKLAHKKV 530
            .|:     :|..::|:
Mouse   493 SYV-----TKFIYRKI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	115/479 (24%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	115/479 (24%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	125/518 (24%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840