DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	561	Identity:	146/561 - (26%)
Similarity:	250/561 - (44%)	Gaps:	78/561 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIIVLLGILGI-----PEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQA 69
            |.:.|.||.|:     ..|.:.|..:.|.|..| |.:..:..::.||..|||...|::
Mouse     5 LCVPLRGISGLLLLLCALPWAEGAKVLVLPMEG-SQWLSMRDVVRELHARGHQTVVLA------- 61

  Fly    70 GAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSL--------------------GVLIREYV 114
                  .|:.:...|||..:......|.|:....:.:                    ...||.:.
Mouse    62 ------SEVTVHIKGEDFFTLKTYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFF 120

  Fly   115 DLHEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMP 179
            ||:   ..:|..|.   |.:..|::..:..:|::||:.. ..|...|||.|.:|.:.:.......
Mouse   121 DLY---SNSCIALL---HNKMLIQQLNSSFFDVILTDPI-FPCGAVLAKYLQIPAVFILRSLSCG 178

  Fly   180 YYYDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYK-----YHSNRADNELVRKY 239
            ..|:....|:..::|.:.....:..:::.:|:.|.:...:||::.:     |.|      |..:.
Mouse   179 IEYEATQCPNPSSYIPNLLTRLSDHMDFLQRVQNMLYYLVLKYICRLSITPYES------LASEL 237

  Fly   240 LGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVH-ITKKAEQELPQNIANFLNQSA 303
            |..||.:.||....:.::|... :.|...||.....|.|||:: :|||   .|.|....::|.|.
Mouse   238 LQREVSLVEVLSHASVWLFRGD-FVLDYPRPIMPNMVFIGGINCVTKK---PLSQEFEAYVNASG 298

  Fly   304 E-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLAL 367
            | |::..|.||||  |.|.|.|...|.|.|...|..::|::.... |...|...:.|||.||..|
Mouse   299 EHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTR-PSNLAKNTILVKWLPQNDL 360

  Fly   368 LCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKK 432
            |.|||.:.|.:|.|..|..|.:..|.|:::.|::|||..||..::.||.|:.|:..::|..:|:.
Mouse   361 LGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLEN 425

  Fly   433 ALAELSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHS 496
            ||..:..| ||.:..:.:|.:..:|...||:.|::.||:|:.:.  .|..|:....:|..:.|||
Mouse   426 ALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHK--GAPHLRPAAHDLTWYQYHS 488

  Fly   497 LDSVALIL---LPLILLILVLC-YLCK-----RNPSKLAHK 528
            ||.:..:|   |.::.::...| |.|:     :...|.:||
Mouse   489 LDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	130/497 (26%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	128/490 (26%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	136/531 (26%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	29/151 (19%)
		egt	<261..505	CDD:223071	84/251 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840178
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840