DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and ugt-3

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506203.2	Gene:	ugt-3 / 191174	WormBaseID:	WBGene00013903	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	129/554 - (23%)
Similarity:	230/554 - (41%)	Gaps:	83/554 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PISAG-NILAVYPHFGFSHFKVVMPILNELAHRGHDITV---ISY--------VKNPQAGAYPNY 75
            |::.| |.|.:.|.||:||.|.:..|.:.||..||::|:   |.|        ||||..... ||
Worm    11 PVAFGFNYLIISPVFGYSHMKFMGRIADILADAGHNVTLFQPIIYDYYAHKKIVKNPNIEVI-NY 74

  Fly    76 E---------------ELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCE 125
            |               :....|.|   |...|:...:|..              .|::|.:..|.
Worm    75 EVDEEEKAAASEASVFKFFWKAKG---SKNPISSAKITSE--------------KLYKEFEHICR 122

  Fly   126 HLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNL----PIIGLSTCALMPYYYDRID 186
            .:.....:.|.|   .:|.:|..::|.|:. |.|.|...|.|    |:.....|....|   .:.
Worm   123 KMLLDKELHRWI---LSKNFDSHISEAFDF-CGLYLGDFLKLKSPIPLYSGVRCGAASY---AVG 180

  Fly   187 LPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEEVAR 251
            .|....::.:|...:..:.:..:||.:.:......|.:....::..::..|...|.....:|:.:
Worm   181 EPIPLNYLPTEGSNYGKKSSAIDRLSDMLGLTGYHFQFGILFDKQYDQAYRLTGGNVRTWQEILQ 245

  Fly   252 TQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFISWGSMVR 316
            :.|.|:..:..| |..|.|...:.::|||..|.......|.:.....|: .....|.:|:|::::
Worm   246 SSTFFLTNSNPY-LSFSTPTISKVIQIGGFTIESFKTTTLDEEFNKILS-LRNNTILVSFGTVIQ 308

  Fly   317 ASSIDEDKLSAILEVLKSQP-LKIIWKWEADE--TPDTDASKFLFVKWAPQLALLCHPKVKLFWS 378
            :|.:.:|..:.::|..:..| ...|||:|.|:  ..:..:...:..||.||.|||...::.||.:
Worm   309 SSDMPDDFKTGLIEAFRRMPDATFIWKYEEDDKTLKNKLSENVVLSKWIPQPALLADSRLDLFVT 373

  Fly   379 HGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAE----LSK 439
            ||||..|.|..:.|...::.|::.||.:||..:...|..:..|..|:.  :.||.:..    |:.
Worm   374 HGGLGSTMEVGYAGVSSIMVPVFSDQGVNAEMLARHGGAIVYDKFDLV--DSKKLMETIQMILNN 436

  Fly   440 NSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIE-----LNGFVYHSLDS 499
            :.|.:.|..:|.:.:.:...|.:..:...|       .|||..|...:|     .|...::.|||
Worm   437 SDYRKNSKRLSDILHNQPMDPKQVLLNHCE-------FAARFAQVDNLEPYANKYNFIEFYCLDS 494

  Fly   500 VALILLPLILLILV----LCYLCKRNPSKLAHKK 529
            :||::..:.::.||    |.::......||..||
Worm   495 LALVVCTISVVALVMFKILSFVVNSVIEKLKLKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	111/489 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	113/504 (22%)
ugt-3	NP_506203.2	egt	1..457	CDD:223071	109/474 (23%)
ugt-3	NP_506203.2	UDPGT	27..525	CDD:278624	119/533 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910