DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and ugt-10

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504313.2	Gene:	ugt-10 / 188619	WormBaseID:	WBGene00020594	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	144/554 - (25%)
Similarity:	238/554 - (42%)	Gaps:	75/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PISAG-NILAVYPHFGFSHFKVVMPILNELAHRGHDITVI-----------SYVKNPQ---AGAY 72
            ||..| |||...|.|||||.|.|..:.:.:|..||::||.           ..:||..   ...|
Worm    15 PIILGKNILIFNPIFGFSHVKFVSKLADIIADHGHNVTVFQPFHIALKNTEGLIKNKNIKFINYY 79

  Fly    73 P-NYEELLISAPGEDQSSTTINLVPL-----TEHTPTRSLGVLIREYVDLHEEGQKTCEHLFASG 131
            | :|:|||         .|.....|:     ..:.|..|..::.:.   |....::|...|...
Worm    80 PDHYDELL---------KTETQTFPMFWDSHLMNNPVVSAVMMAKA---LSSTFERTATQLVKD- 131

  Fly   132 HIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTPAFIQS 196
              :..:...::|.:|::::|.|.. ..:.:|.|:|:|.|.:.:......:......|.|..:|..
Worm   132 --QNVLNNLKSKKFDVMISETFEL-TGMYVAHLINVPCIPIWSAVRFLVFNKAFGQPSTLGYIPL 193

  Fly   197 EFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEEVARTQTAFIFGNQ 261
            |....|....:.:| ||.|.......:......:..|.::.|.:|..|...:...:|:.....|.
Worm   194 EGSKMAPDFGFFDR-LNDVYRDFFGQIGMDRLGQYQNNIIEKAVGHSVPYWKDLVSQSPIYITNS 257

  Fly   262 HYSLMGSRPQSLQFVEIGGVHITK---KAEQELPQNIANFLNQSAEGVIFISWGSMVRASSIDED 323
            :..|..:...:...|.|||:.|..   |...|||:.....| |..|..:.||:||::|:..:.::
Worm   258 NPYLDFAVATTPAIVHIGGITIDLEKIKHADELPEEYEKIL-QERESTVLISFGSVIRSYEMPDN 321

  Fly   324 KLSAILEVLKSQP-LKIIWKWEADETPDTDASKFL-----FVKWAPQLALLCHPKVKLFWSHGGL 382
            ..:.::::.:|.| :..|||:|.|   |.:..|.|     ..||.||.:||...:||||.:||||
Worm   322 FKAGLIKMFESLPDVTFIWKYERD---DVEFQKRLPKNVHLKKWVPQPSLLADKRVKLFVTHGGL 383

  Fly   383 LGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDI-TVPNLKKALAEL------SKN 440
            ..|.|..:.|||.|..||:|||..||..:...|..:..|..|: ....|.|.:.|:      |||
Worm   384 GSTMEVAYTGKPALSVPIFGDQPENADMLARHGGAIAYDKFDLANGEKLTKTVREMVTNPKFSKN 448

  Fly   441 SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYH-SLDSVALIL 504
            :.|.|.:.:.:        |::..:..::|:...........|.|.|...|::.| .||.:|.
Worm   449 AEALRDVLLKQ--------PIDPKMNLMKHLEFAMEFPNHRSQVPAINKLGWIAHYYLDVIAF-- 503

  Fly   505 LPLILLILVLCYLCKRNPSKLAHKKVG---KKPK 535
              |.|:::...||..|. :|:...::|   ||.|
Worm   504 --LTLVVVGFLYLIFRF-TKIVFVRIGILNKKAK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	126/488 (26%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	124/499 (25%)
ugt-10	NP_504313.2	egt	1..463	CDD:223071	125/476 (26%)
ugt-10	NP_504313.2	UDPGT	31..535	CDD:278624	135/538 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850