DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and ugt-56

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506074.2	Gene:	ugt-56 / 188073	WormBaseID:	WBGene00011453	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	129/558 - (23%)
Similarity:	225/558 - (40%)	Gaps:	115/558 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYPNYE 76
            ||.||.|.|..  ||.:||...|....||......|.|.||.|||.:|||..|.        .|:
Worm     6 IVWLGALCIYG--SAFDILIYAPRMMQSHVYFTARIANVLAARGHKVTVIDNVF--------RYD 60

  Fly    77 ELLISAPGEDQSSTTINLVPLTEHTP-------TRSLGVLIREYVDLHEEGQKTCEHLFASGHIE 134
            .       :::.|:.|:.:...|.:|       |.||..::.......||.:...|.|   ||:.
Worm    61 V-------DNELSSDIHEIISVEPSPEVTKLLNTGSLPTILWNSKASPEEQRTIMEGL---GHVH 115

  Fly   135 R-----------AIERHRNKPYDLLLTEYFNSDCQLALAKLLNL--PIIGLST--CALMPYYYDR 184
            |           .|.:.:...:|..:.|.|:| |.:.:.:::.:  .:|..||  ..::|.....
Worm   116 RLQCTHLIENSTLIPKLQEIKFDFAIHEVFDS-CGVGILEVIGVQKTVIVSSTGPMDVVPITLGI 179

  Fly   185 IDLPDTPAFIQ--SEFVGF----------AGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVR 237
            .|..:||:.:.  ..::.|          :|.||:||     :|..::..|:|
Worm   180 SDTLNTPSLLSDYGSYLSFFEKRRNLKFLSGMLNFHE-----MQDSMISPLFK------------ 227

  Fly   238 KYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQS 302
            ||.|::....|:.| |...:|.|.|....|.|.:..:..:|||  |..|.::.|.......|:..
Worm   228 KYYGLKKPTGEIMR-QANLLFYNIHEGSDGMRMRGRRSFDIGG--IAFKDQKNLTMEYQTLLSDP 289

  Fly   303 AEGVIFISWGSMVRASSIDEDKLSAILEVLKS-QPLKIIWKWEADET---PDTDASKFLFVKWAP 363
            ...|: :|:|:...:|.:.::..::::..:|. ..:..|||:|.::.   .:...:..:|.|:.|
Worm   290 RPKVL-VSFGTAATSSHMPQNLKNSLMTAMKQMNNVLFIWKYEMEDNFTKQEELTTNIIFKKFLP 353

  Fly   364 QLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVP 428
            |..||...|:.||.:|.|.....|:.:.|..:|..|::|||..||......|:...|...||..|
Worm   354 QTDLLASSKIDLFVTHCGQNSLLEAFNSGVRVLAVPLFGDQHRNAKLAFENGLIEILPKSDIETP 418

  Fly   429 N--LKKALAELSKNSYAQRSLE-VSKVFNERQQTPLESAIWSVEHVIS----------------N 474
            .  :|.....|..|:...:::. :|.:....::......|.::|...|                |
Worm   419 AKIVKAVKTGLEPNAKLDQNIVLISSLLRNSKENAENLLISTIEATYSTEFPPNFSKFPKNYHPN 483

  Fly   475 GLIAARLLQSPGIELNGFVYHSLDSVALILLPLILLIL 512
            .|:  ||:.|              |:||:.:..|.:.:
Worm   484 TLV--RLIDS--------------SIALVFMLFIFVFV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	120/519 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	115/519 (22%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<216..>399	CDD:299143	50/203 (25%)
ugt-56	NP_506074.2	Glycosyltransferase_GTB_type	<353..453	CDD:299143	27/99 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850