DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and ugt-50

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_741913.1	Gene:	ugt-50 / 181413	WormBaseID:	WBGene00011564	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	124/551 - (22%)
Similarity:	230/551 - (41%)	Gaps:	87/551 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYPNYEELLISAPGEDQS 88
            ::|..||...|....||..:.....:.|.:.|||..:.          .|:|.:||.:..|...:
Worm    23 VNAAKILVYCPSISKSHVLLCSKYADLLHNAGHDTVLF----------IPSYSKLLDNYDGAKHA 77

  Fly    89 STTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHLFASGHIER------------------ 135
            ... .|..:||...|: ||.|.....:.|            .|.|:|
Worm    78 KVW-RLHNVTEAYDTK-LGTLANVMENSH------------IGFIDRLTFDADFWIDMCADLLGK 128

  Fly   136 --AIERHRNKPYDLLLTEYFNSD-CQLALAKLLNLP-IIGLSTCALMPYYYDRIDLPDTPAFIQS 196
              .::...:..:||::  |...| |..|:.:|.|:| .:.||:.|:|......:.||..|:::.|
Worm   129 LPEMQHIIDYKFDLVI--YNEIDPCTPAIVRLFNIPKTVLLSSEAIMDKVAWNLGLPTLPSYVPS 191

  Fly   197 -EFVGFAGQLNWHERLLN---FVQAKLLKFLYKYHSNRADNELVRKYLGVEV-DVEEVARTQTAF 256
             |......::::.||:.|   |.|:.::.:|...|.    ..|.||.:..:. .:.|:.|..:..
Worm   192 VEENPNHDRMSFFERMSNVYKFFQSIVVHYLQDIHV----LNLFRKEVSSDFPSIAEIIRNVSLV 252

  Fly   257 IFG-NQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFISWGSMVRASSI 320
            :.. ::.:.|  .|..|.:||.:|.:...|.....||:...::..:...|.:|:|:|::....|:
Worm   253 LVNTDEIFDL--PRSYSSKFVYVGMLEAGKDENVTLPKKQDDYFKKGKSGSVFVSFGTVTPFRSL 315

  Fly   321 DEDKLSAILEVLKSQP-LKIIWKWEADETPDTDASKFL-------FVKWAPQLALLCHPKVKLFW 377
            .|....:||..::..| ...:.|..||   |..:::|.       .|.|.||.|:|.|..:|||.
Worm   316 PERIQLSILNAIQKLPDYHFVVKTTAD---DESSAQFFSTVQNVDLVDWVPQKAVLRHANLKLFV 377

  Fly   378 SHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKAL-AELSKNS 441
            ||||:....|:::.|.|:::.|::.|||.|..:|:.||.|..:..:.:.......|: :.|.:.|
Worm   378 SHGGMNSVLETMYYGVPMVIMPVFTDQFRNGRNVERRGAGKMVLRETVVKETFFDAIHSVLEEKS 442

  Fly   442 YAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALILLP 506
            |:.....:|.:...:..|..|.....::.|:.........|:|..:.:  ..::.||
Worm   443 YSSSVKRISHLMKNKPFTSEERVTKWIDFVLKYETSEHFDLESNNLSI--IEHNHLD-------- 497

  Fly   507 LILLILVLCYLCKRNPSKLAHKKVGKKPKRS 537
               |...||.:...|  .:.::|:.|:..:|
Worm   498 ---LFFYLCIISLLN--FVVYRKIFKRKSQS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	113/487 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	113/499 (23%)
ugt-50	NP_741913.1	egt	9..475	CDD:223071	113/486 (23%)
ugt-50	NP_741913.1	UDPGT	26..520	CDD:278624	122/543 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920