DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and ugt-23

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001076755.1	Gene:	ugt-23 / 181205	WormBaseID:	WBGene00007650	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	138/543 - (25%)
Similarity:	254/543 - (46%)	Gaps:	68/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRSGVLIIVLLGILGIPEPISAGNILAVYPH-FGFSHFKVVMPILNELAHRGHDITVI-----SY 63
            |.|.:|:.:|..       :|:...:.||.: ||.||.|.|..:::.|...|||:||:     |.
Worm     3 LLSALLLQILFN-------VSSPYKILVYSNLFGHSHIKFVGSVVDTLVDAGHDVTVVLPVIDST 60

  Fly    64 VKNP---QAGAYPNYEELLISAPGEDQSSTTINLVPLTE----HTPTRSLGVLIREYVD---LHE 118
            .||.   ::||    ::::|.|..|     .:.:...||    :..|..:...:..:::   |.:
Worm    61 QKNRTSIKSGA----KQIIIDADEE-----VVEIFSQTEKFLSNMWTMEMSNPLMMWMNPRILTQ 116

  Fly   119 EGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPI-IGLSTCALMPYYY 182
            ...|.|..:.   .:...:::.:::.:||.:||.|:| |...:.:.|.:|. :.:.:||.|.:..
Worm   117 LFGKQCTKVM---KLSELLDQLKSEKFDLAITEAFDS-CGYGIFEYLQIPAHVSILSCARMDHVS 177

  Fly   183 DRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQ----AKLLKFLYKYHSNRADNELVRKYLGVE 243
            |.:..|..|:::......::.::...:|.||::|    ..:...:..|.|..|     :|.||||
Worm   178 DVLGQPIAPSYVPGTQSLYSDRMTMTQRFLNYLQFLNGNSMFSDIGDYESANA-----KKLLGVE 237

  Fly   244 VDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQ-ELPQNIANFLNQSAEGVI 307
            ....|:. .:::|:..|....|....|...:.|.|||:.:.|..|. :|.......::...:.||
Worm   238 RSWREIL-PESSFLLTNHIPVLEFPAPTFDKIVPIGGISVNKNKETLKLEHYFDTMVSMRKKNVI 301

  Fly   308 FISWGSMVRASSIDEDKLSAILEVLKSQP-LKIIWKWE--ADETPDTDASKFLFVKWAPQLALLC 369
             ||:||.:::..:.::...::.|:.:..| :..|||:|  ||:...........|:|.||..||.
Worm   302 -ISFGSNIKSMDMPDEYKKSLAELFQLMPDVTFIWKYENLADKKYTCGIMNINRVEWIPQTELLA 365

  Fly   370 HPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVP-NLKKA 433
            ..:|..|.:||||...||....|||.:|.||:.||..||..::..|....|...|:..| .|:|.
Worm   366 DSRVDAFITHGGLGSVTELATMGKPAVVIPIFADQTRNAEMLKRHGGAEVLHKTDLANPETLRKT 430

  Fly   434 LAELSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNG-----F 492
            |.::..: ||.|.:..::::.|.:...|.|:.:..||       .|||..:.|.::..|     .
Worm   431 LRKVMDDPSYRQNAQRLAEMLNNQPTNPKETLVKHVE-------FAARFGKLPSMDPYGRHQNII 488

  Fly   493 VYHSLD--SVALILLPLILLILV 513
            .|::||  ::|.|||.|::.:.:
Worm   489 EYYNLDILAIATILLTLVVYLKI 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	123/493 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	124/495 (25%)
ugt-23	NP_001076755.1	UDPGT	20..526	CDD:278624	133/519 (26%)
ugt-23	NP_001076755.1	Glycosyltransferase_GTB_type	40..474	CDD:299143	115/460 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.970