DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and ugt-57

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_509182.1	Gene:	ugt-57 / 180969	WormBaseID:	WBGene00017154	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	570	Identity:	130/570 - (22%)
Similarity:	231/570 - (40%)	Gaps:	85/570 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLLGILGIPEPISAGNILAVYPHFGFSHFK--VVMPILNELAHRGHDITVISYVKNPQAGAYPNY 75
            :|:.:||:.:.:::.|||...  .|.:.|:  :...:..:||.|.|::..|..|..|:.   |..
Worm     3 ILILLLGLTQIVTSLNILVFL--LGTNQFERNIFEFLAQQLALRHHNVISIKPVLIPEE---PRL 62

  Fly    76 ---------EELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHLFASG 131
                     |:::.:...:|......:.||......|......:..|...|   ..:|..|..|
Worm    63 VKPKLHLVREKVIKNVLNKDLFKPLEDAVPNAAWRSTYDFDNYLEPYYKAH---NASCYKLLNS- 123

  Fly   132 HIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDR------------ 184
               ..::..:.:..||.:. |..:.|..||..|:.:|.|          |:|.
Worm   124 ---NLVDSLKKESLDLAIV-YSGNPCLNALTHLVAVPTI----------YFDTEGLTDETLIAAG 174

  Fly   185 --IDL--PDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHS------NRADNELVRKY 239
              |||  |.:..|| :|..|:. .||.::..:.:.|..:.:......|      :|..:|.:...
Worm   175 APIDLLTPPSHCFI-AESKGYP-ILNLYKNSVCYFQEMIAQLGLPAVSSLVSSRHRLLDEPITNI 237

  Fly   240 LGVEVDVEE---------VARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNI 295
            ...:..:::         ..:.|:|..|.|....|...|...|..:.:||:||........|.|.
Worm   238 FRTDYTIKKRFKNFPNVNTLKQQSAAYFVNTDPLLEPPRALPLNVIPVGGLHIDHPKPLFSPWNT 302

  Fly   296 ANFLNQSAEGVIFISWGSMVRASSIDEDKLSAILEVLKS-QPLKIIWKWEADETPD-TDASK--- 355
            .  :..:.||:|.:|:|:...:|.:.|....|||:.|.: ...:|.|:...:...| .|..|
Worm   303 T--IASAKEGLIIVSFGTQADSSKMSEYHAKAILKALTNLNDYRIYWRIGPNMHLDGIDIEKIPK 365

  Fly   356 -FLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLK 419
             .....:.||..||.|...|||.::||:....|:|..|.|::..|:||....|...|.|:|:|:.
Worm   366 HINLTTFIPQNDLLAHKSCKLFVTNGGMSSVMEAVAHGVPIVGVPLYGSNRYNLQKVSNKGLGIV 430

  Fly   420 LDYQDITVPNLKKALAE-LSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQ 483
            :|..|:...:|..|:.: |....|...:.|:||.|..|..:|..:|:..::|:   |...:....
Worm   431 IDKDDLNEISLYGAMKKVLESAKYKNTAKEMSKEFKSRTTSPFAAALHVIDHI---GRHHSFAYM 492

  Fly   484 SPGIELNGFVYHSLD---SVALILLPLILLILVLCYLCKRNPSKLAHKKV 530
            .|..:.   :|..:|   .:.:||||:|.|.|...:..|.:...:...||
Worm   493 QPAFQP---IYTRVDFYLLLLIILLPVIPLHLFFTFCIKSSAMNVQDNKV 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	116/510 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	113/514 (22%)
ugt-57	NP_509182.1	GT1_Gtf-like	<168..477	CDD:340817	77/312 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910