DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and ugt-5

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_506200.1	Gene:	ugt-5 / 179753	WormBaseID:	WBGene00013906	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	561	Identity:	145/561 - (25%)
Similarity:	242/561 - (43%)	Gaps:	82/561 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI-----------SY 63
            ||.|||.|    :.:::.|.|.:.|.:||||.|.:..|.|:||..||.:|..           ..
Worm     8 LIFVLLFI----KNVASYNFLVISPVYGFSHMKSMAIIANQLADAGHQVTYFQPFVVELFKDHDL 68

  Fly    64 VKNPQAGAYPNY---EELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCE 125
            :|||.. ...||   ||...:.||....|..     .|.:.....:|..|.....||:..|:.|.
Worm    69 IKNPNI-EIMNYFHDEEGKKNIPGHSVLSDA-----WTSYKYQSDVGQKIFAPRILHQSFQEMCR 127

  Fly   126 HLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLP-IIGLSTCALMPYYYDRIDLPD 189
            |:|....:.|.:   ::|.:|::|:|.|:. |.|.||..|.:| ||.:.|...:....:.:..|.
Worm   128 HMFEDEALHRQL---KDKKFDVVLSETFDF-CGLYLADYLEMPAIISVFTGNRLNAITNALGEPS 188

  Fly   190 TPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELV-RKYLGVEVDVEEVAR-- 251
            ...::.|....|...::.::|..|        |.:|..|:....||. |:|..|.......||
Worm   189 FLHYLPSPSSSFNANMSLYDRFNN--------FWHKILSSSTFGELFDRQYADVYRLTNGKARHW 245

  Fly   252 ----TQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFISWG 312
                ....:.|.|.:..|....|...:.:.|||..:..|....:.:::...||..: ..:|||:|
Worm   246 KQILNDVTYHFSNSNPYLDFVIPTIAKVIPIGGYTMDYKQVPPVSKDLDTILNLRS-STVFISYG 309

  Fly   313 SMVRASSIDEDKLSAILEVLK-SQPLKIIWKWEADETPDTDASKFL---------FVKWAPQLAL 367
            :|:.|..:.::...::::..| ::.:..:||:|..|      .||:         ...|.||.:|
Worm   310 TMISAKYMPDEYKQSMIDFFKDNKNVTFLWKYEEPE------EKFIKENIPDNVHLSTWFPQQSL 368

  Fly   368 LCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKK 432
            |...:||||.:||||..|.|..:..||.:|||::.||..||..::..|....|...||  ||.||
Worm   369 LADKRVKLFITHGGLGSTMELAYSAKPAIVTPLFADQPSNAQMLERHGSVEVLSKHDI--PNWKK 431

  Fly   433 ----ALAELSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFV 493
                ....|:...|.:.:..::.:.|.:..:|.|..:...|:....|.|.:   .:|..:..||:
Worm   432 QSDLLKTMLADKKYQEAATRLADILNNQPISPRELMLKHAENAARFGKIPS---LTPFAKDMGFI 493

  Fly   494 -YHSLD----SVALILLPLILLILVL-----CYLCKRNPSK 524
             ::::|    ||:..|..:.:.|.:.     |  ||....|
Worm   494 EFYNIDLIIYSVSFTLFAIYVTIEIFGIVKNC--CKTRKLK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	131/500 (26%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	128/503 (25%)
ugt-5	NP_506200.1	egt	6..509	CDD:223071	139/534 (26%)
ugt-5	NP_506200.1	UDPGT	32..527	CDD:278624	132/526 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850