DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and ugt-11

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	140/551 - (25%)
Similarity:	239/551 - (43%)	Gaps:	84/551 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI-----------SYVKNPQ---AGAYP-NY 75
            |..||...|.|||||.|.|..:.:.:|..|.::|:.           ..|||..   ...|| :|
Worm    18 AAKILIFNPIFGFSHVKFVSKLADIIADHGQEVTLFQPFHLALKNLDGIVKNKNIEIINYYPDHY 82

  Fly    76 EELLISAPGEDQS------STTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHLFASGHIE 134
            ::||   ..|.|:      |..:|...|......|.||          .|.:||...|.....|
Worm    83 DDLL---KLETQTFPDFWDSQLMNNPVLMAFMLPRILG----------GEFKKTTIQLIKDKEI- 133

  Fly   135 RAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTPAFIQSEFV 199
              :::.::|.:|:.::|.|.. ..:.::..|.:|.|.:.:..       |:|: ...||.||...
Worm   134 --LKKLKDKKFDVAISETFEL-TGMYMSHFLGVPCIPILSAV-------RLDI-FNEAFGQSSAF 187

  Fly   200 GF--------AGQLNWHERL----LNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDV-EEVAR 251
            |:        |....:.:||    .:|......:.:.:|     .|:::.|..|..|.. :::.:
Worm   188 GYLTQQGSKLAPDAGFLDRLNDVYRDFFSKMAFRGMAQY-----QNDVIEKAAGHVVPYWKDLVK 247

  Fly   252 TQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQE---LPQNIANFLNQSAEGVIFISWGS 313
            ....::..:..| |..:.|.:...|.|||:.|..:....   ||:.....|.:. |..:.||:||
Worm   248 EAPVYMTNSNPY-LDFAVPTTATIVHIGGITINLEKMNHVDALPEEYEIILKEK-ETTVLISFGS 310

  Fly   314 MVRASSIDEDKLSAILEVLKSQP-LKIIWKWEADETPDTDASKFL-----FVKWAPQLALLCHPK 372
            ::|:..:.|:..:.:::|.:|.| :..|||:|.|   |.:..|.|     ..||.||.:||...:
Worm   311 VIRSYEMPENFKAGLIKVFESLPDVIFIWKYEID---DLEFQKKLPKNVHLKKWVPQPSLLADKR 372

  Fly   373 VKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQD-ITVPNLKKALAE 436
            ||||.:||||..|.|..:.|||.|:.||:|||.:||..:...|..:..|..| :....|.:.:.:
Worm   373 VKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPMNADMLARHGGAIAYDKFDLVDGKKLTETVRD 437

  Fly   437 LSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYH-SLDS 499
            |..| .|.|::.|:..|...:...|:.:.:..:|..|....:.:   |.|.|...|.:.| .||.
Worm   438 LVTNPKYEQKAKELLDVLTNQPIDPVMNLMKHLEFAIKFPNLRS---QIPEINQVGPIAHYYLDV 499

  Fly   500 VALILLPLILLILVLCYLCKRNPSKLAHKKV 530
            :..::...|:...:...:..|..|::..|||
Worm   500 IVFLIFVSIITAYISFQIVCRILSRILSKKV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	127/493 (26%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	128/508 (25%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	82/306 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161503
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850