DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and ugt-45

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	137/578 - (23%)
Similarity:	241/578 - (41%)	Gaps:	106/578 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYP 73
            ||:.:||.:|   ...|...||...|.|||||.:.:..:.:.|...|||:|.:..|..|
Worm     3 VLVFLLLFVL---PAASCYKILVSVPKFGFSHMQTMGKLADILVEAGHDVTFLMPVDVP------ 58

  Fly    74 NYEELLISAPGEDQSSTTINLVPLTE--------------------HTPTRSLGVL----IREYV 114
                    .|........:.|||.|:                    |:.....|::    :...|
Worm    59 --------IPQNGTELAKVVLVPTTDAINEIMGHAMKSGAVANLWTHSANSKQGIMWSTDMIGQV 115

  Fly   115 DLHEEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLP-IIGLSTCALM 178
            ..|     ..::|..:   :..:::.:::.:|:.:||.|:.. .||..:::.|. ::|..|.::.
Worm   116 SYH-----NTKNLIDN---KALVQQMKDEKFDIGITELFDFS-GLAFFEVIGLKNVMGAHTTSVF 171

  Fly   179 PYYYDRIDLPDTPAFIQSE--FVGFAG----QLN------WHERLLNFVQAKLLKFLYK-YHSNR 230
            .........|..|:|:.:.  |...:|    :||      |..:..|.:|:...|.|.: |...:
Worm   172 EGTLMATGAPILPSFVPASQTFTDDSGSILSRLNNLYMTYWSYQFQNKIQSFAQKALDEHYEKGK 236

  Fly   231 ADNELVRKYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHI--TKKAEQELPQ 293
            |.     |...:..|:        .:.|.|........:|.....|||.|:.:  .|...:|..:
Worm   237 AP-----KIWNLVSDI--------TWFFVNSDPIFDFPKPLPQNIVEIAGISVPEIKPVGKEWDE 288

  Fly   294 NIANFLNQSAEGVIFISWGSMVRASSIDEDKLSAILEVLKSQP-LKIIWKWEADETPDT-DASKF 356
                .|::.::.|: :|:||:...:::.|....:|::...:.| :..|||::..|:..| .....
Worm   289 ----ILSKRSKNVL-VSFGSIASPTTMPEAVKKSIVDAFAAFPDVTFIWKYDDTESKLTAHLDNV 348

  Fly   357 LFVKWAPQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLD 421
            ..|||.||..||...::.:||:|||:....||.....||:|.||:|||..||...:..|:.|..|
Worm   349 HIVKWMPQNDLLADKRISMFWTHGGMGSLMESAQKSVPLVVVPIFGDQMRNAQIAKRHGVALIYD 413

  Fly   422 YQDITVPNLKK---ALAELSKNSYAQRSLE-VSKVFNERQQTPLESAIWSVEHVISNGLIAARLL 482
            ..|::  |.||   ||.|:.:|...::|.| ::::....:.:|.:..|.:||       :|.|..
Worm   414 KMDLS--NTKKLIGALKEVLENPEYKKSAELLARILATERFSPRQKIIDTVE-------MAGRFG 469

  Fly   483 QSP-----GIELNGFVYHSLDSVALILLPLILLILVLCYLCKRNPSKLAHKKVGKKPK 535
            |.|     |.|.:...|.:||.|.:.:....|.|:....|.:...:||...  |.|.|
Worm   470 QMPRWTSAGKEFSFLKYFNLDLVIIAVFIFFLSIVSTVLLIRHLLAKLGFS--GDKEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	119/511 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	117/513 (23%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	127/548 (23%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	125/540 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.970