DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and ugt-62

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_497918.1	Gene:	ugt-62 / 175591	WormBaseID:	WBGene00010904	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	125/547 - (22%)
Similarity:	242/547 - (44%)	Gaps:	54/547 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI--SYV-------- 64
            ||.:.|.:||   .:||.......|:...|..:....:...||:.|||:|:|  |::
Worm     3 LIALFLLLLG---AVSAYKYAVFVPYMANSQVQFCTRVAEVLANGGHDVTMIHLSHLPDYKTDVK 64

  Fly    65 --KNPQAGAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHL 127
              ||.:......|.|.|..|..|.:.|..|     .:.|..:.:..::..:....:..|..|.::
Worm    65 IPKNIKVHRVEAYVEGLTKALLEKEQSAFI-----FKDTGLKDMPAMMSMFSRFGKMFQDGCRNI 124

  Fly   128 FASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPI-IGLSTCALMPYYYDRIDLPDTP 191
            ..:....:.:|   |:.:|:..: |..|.|.:.|.....:|. :.|::.|||.:..:.:.:|..|
Worm   125 VRNKEFMKWLE---NEKFDVAYS-YIYSSCPIGLIHAAKIPSWVWLNSGALMDFVAETVGVPIIP 185

  Fly   192 AFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYL---GVEVDVEEVARTQ 253
            :::....:....::.:..|:.:|:...|:..|::..::..:.::.|..|   .....::..|:..
Worm   186 SYVPPLMMESDDEMGFFFRMKSFIGHTLMTVLHRRMTSNGETQIFRDELNDPNFPHTMDLGAKCP 250

  Fly   254 TAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVIFISWGSMVRAS 318
            ...:..|:.|.|  .||...:.|.|||:.:...:.:.|...... ::::.:|:|..|:||:..|.
Worm   251 LVIVNSNELYDL--PRPTLAKVVNIGGLGVGFDSAKPLTGEFKK-ISETGKGMIVFSFGSVAAAH 312

  Fly   319 SIDEDKLSAILEVLKSQP-LKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGGL 382
            .:..:..::|||...|.| .:.:.::.||:..|.........||.||..||.|.|.|.|.:|||.
Worm   313 DMPLEWKNSILEAFSSLPDYQFLMRYVADDLNDRLPKNVHLFKWLPQKDLLLHNKTKAFITHGGY 377

  Fly   383 LGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN-SYAQRS 446
            ....|::..|.||:...::|||..|:...:..|..:.:...:|:...:.||:.|:.:| ||.|:.
Worm   378 NSMQEAISAGVPLVTIALFGDQPKNSKVAKKHGFAVNIQKGEISKKTIVKAIMEIVENDSYKQKV 442

  Fly   447 LEVSKVFNERQQTPLESAI-WS---VE-HVISNGLIAARLLQSPGIELNGFVYHSLDSVALILLP 506
            ..:|.:...:...|.|..: ||   .| ..:.|       |:..|.:||.|.|||||.:..:.:.
Worm   443 SRLSAMVRAQPMKPAERLLKWSEFLAEFKTLDN-------LEPAGQKLNFFQYHSLDVITFLFIV 500

  Fly   507 LILLI---------LVLCYLCKRNPSK 524
            :.::.         ::.|..||:..:|
Worm   501 IFIVFYIGYRFMRAVIRCCFCKKCETK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	110/487 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	113/485 (23%)
ugt-62	NP_497918.1	UDPGT	37..520	CDD:278624	113/501 (23%)
ugt-62	NP_497918.1	egt	<251..471	CDD:223071	60/222 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161328
Domainoid	1	1.000	172	1.000	Domainoid score	I2232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850