DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and ugt-26

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_491435.2	Gene:	ugt-26 / 172085	WormBaseID:	WBGene00015695	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	136/557 - (24%)
Similarity:	248/557 - (44%)	Gaps:	74/557 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYV----KNP 67
            |.|.|.::|..|.:   :|:.|||...|.:..||...:..:.:.|...||::|.:..:    :..
Worm     5 SVVSISLVLCTLSL---VSSLNILVHSPAYAASHTNFMARLADTLTEAGHNVTFLVPIALEERRD 66

  Fly    68 QAGAYPNYEELLISAPGEDQS-----STTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHL 127
            :.|.....:.:::....|.:|     |.:|..:.:.| ..:.|:..:...|   :|....|||:.
Worm    67 KLGVKLTKDVIIVEQDEEMKSKLVPHSGSIEFLWIIE-MDSSSIDAMFSWY---NEIMILTCENF 127

  Fly   128 FASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNL-PIIGLSTCA----LMPYYYDRIDL 187
            ..:   ::.:...:::.:|:.:.|.| :.|.|.|.:.||: ..|.:|:||    ::|:..:..|.
Worm   128 MRN---KQVMSELKSRHFDVAIAEPF-TICGLGLFEELNIKKTILVSSCAHYDFMLPHIGEPEDF 188

  Fly   188 PDTPAFIQSEFVGFAGQL--NWHE-RLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEEV 249
            ...|..  |..||....:  .|.. ||:...:|.|.|..      .|:..:.|:..|.::...:.
Worm   189 SSVPTL--SSKVGEEMSMTEKWENYRLVAETKASLAKLF------DAETRIYRESFGSDIPDWKE 245

  Fly   250 ARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAEGVI------- 307
            ..:..:..|.|.:..:...|....:.:.|||:.:      :..|..:..||:..|.|:
Worm   246 LMSSASLYFTNSNPFIDYPRASIQKTISIGGITV------DFQQIKSEKLNKEWEEVLNKRQKSM 304

  Fly   308 FISWGSMVRASSIDEDKLSA-----ILEVLKSQP-LKIIWKWEADETPDTDA-SKFLFVKWAPQL 365
            .||:|     |::..||:.|     |.|.:||.| :..|||:|:|:....|. |...|.||.||.
Worm   305 LISFG-----SNVPSDKMPAAWKAGIFETIKSMPNVTFIWKYESDDVSFADGISNIHFSKWVPQT 364

  Fly   366 ALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDI-TVPN 429
            |||..|::..|.:||||..|.|..:|.||.::.||||||..||..:...|..:.|..::: .|..
Worm   365 ALLNDPRLSAFLTHGGLGSTNELAYCAKPAVMVPIYGDQTRNANMLARHGSVIVLHKKELANVQR 429

  Fly   430 LKKALAELSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFV 493
            :|||:.::..| .|.:.:..::::...:.:||.|:.:...|.|...|....  :...|.:|..|.
Worm   430 VKKAVHDILYNKQYTESAERIAEMIKNQPKTPKETVVRYTEFVAKYGPFPQ--MAPHGRKLTYFQ 492

  Fly   494 YHSLDSVALILLPLILLILVL---------CYLCKRN 521
            ...||..:|..|.::.::.|.         |:..|::
Worm   493 KTFLDIYSLFALGVVSVLTVAFLVIRYVLSCFKLKKD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	124/499 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	121/495 (24%)
ugt-26	NP_491435.2	egt	4..481	CDD:223071	126/507 (25%)
ugt-26	NP_491435.2	UDPGT	34..525	CDD:278624	125/519 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161468
Domainoid	1	1.000	172	1.000	Domainoid score	I2232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.900