DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	133/539 - (24%)
Similarity:	240/539 - (44%)	Gaps:	72/539 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYPNY--EELLISAPGED-- 86
            ||.:|.| |..| ||:..:..::.:|..:||::.|:....:.|.|...|:  :...:|...||
  Rat    25 AGKLLVV-PMDG-SHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKPLNFTVKTYSVSHTQEDLN 87

  Fly    87 -----------QSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTCEHLFASGHIERAIERH 140
                       ::.....::||.. :|.:....|:..:          |..||..   ::.:|..
  Rat    88 REFKFFIDSQWKTQQEGGVLPLLT-SPAQGFFELLFSH----------CRSLFKD---KKLVEYL 138

  Fly   141 RNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRIDLPDTPAFIQSEFVGFAGQL 205
            :...:|.:..:.|:. |.|.:||..:||.:..|......|..:....|..|:::....:.....:
  Rat   139 KQSSFDAVFLDPFDV-CGLTVAKYFSLPSVVFSRGIFCHYLEEGSQCPSPPSYVPRGILKLTDTM 202

  Fly   206 NWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDV-EEVARTQTAF--IFG-------N 260
            .:.||:.|     ||.::       .::.....:.....|: .||.:|....  :|.       .
  Rat   203 TFKERVWN-----LLSYM-------GEHAFCPSFFKTATDIASEVLQTPVTMTDLFSPVSVWLLR 255

  Fly   261 QHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSIDEDK 324
            ..::|...||.....:.|||::..::  :.|.:....::|.|.| |::..|.||||  |.|.|.|
  Rat   256 TDFTLELPRPVMPNVIHIGGINCHQR--KPLSKEFEAYVNASGEHGIVVFSLGSMV--SEIPEKK 316

  Fly   325 LSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTESV 389
            ...|.|.|...|..::|::.... |...|...:.|||.||..||.|||.:.|.:|.|..|..|.:
  Rat   317 AMEIAEALGRIPQTVLWRYTGTR-PSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGI 380

  Fly   390 HCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN-SYAQRSLEVSKVF 453
            ..|.|:::.|::|||..||..::.||.|:.|:..::|..:|:.||..:..| ||.:..:.:|.:.
  Rat   381 CNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLH 445

  Fly   454 NERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALIL---LPLILLILVLC 515
            .:|...||:.|::.||:|:.:.  .|..|:....:|..:.|||||.:..:|   |.::.::...|
  Rat   446 KDRPIEPLDLAVFWVEYVMRHK--GAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSC 508

  Fly   516 -YLCK-----RNPSKLAHK 528
             |.|:     :...|.:||
  Rat   509 AYGCRKCFGGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	117/475 (25%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	119/489 (24%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	129/531 (24%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	78/247 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910