DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	155/555 - (27%)
Similarity:	245/555 - (44%)	Gaps:	69/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQA 69
            |.:|.|.:||.|.:       .|:.|.|.|..| ||:..:..|:..|:.|||||.|:....|...
  Rat    10 LPAGFLFLVLWGSV-------LGDKLLVVPQDG-SHWLSMKEIVEHLSERGHDIVVLVPEVNLLL 66

  Fly    70 GAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLG-----------VLIREY------VDLH 117
            |....|.......|        .||..|  .|..||.|           ..:|||      :|:
  Rat    67 GESKYYRRKSFPVP--------YNLEEL--RTRYRSFGNNHFAASSPLMAPLREYRNNMIVIDM- 120

  Fly   118 EEGQKTCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGL---STCALMP 179
              ...:|:.|...   ...:...|...:|.|.|:. ...|.:.||:.|.||.:.|   ..|:|..
  Rat   121 --CFFSCQSLLKD---SATLSFLRENQFDALFTDP-AMPCGVILAEYLKLPSVYLFRGFPCSLEH 179

  Fly   180 YYYDRIDLPDTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEV 244
            .....   |...:::...:..|:..:.:.:||.||: |.:|: .|.||...:..|::...| ::.
  Rat   180 MLGQS---PSPVSYVPRFYTKFSDHMTFPQRLANFI-ANILE-NYLYHCLYSKYEILASDL-LKR 238

  Fly   245 DVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIF 308
            ||...|..|.:.......:.....||.....:.|||.:..||.  .|.|....::|.|.| |::.
  Rat   239 DVSLPALHQNSLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKG--NLSQEFEAYVNASGEHGIVV 301

  Fly   309 ISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKV 373
            .|.||||  |.|.|.|...|.|.|...|..::|::.... |...|...:.|||.||..||.|||.
  Rat   302 FSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTR-PSNLAKNTILVKWLPQNDLLGHPKA 363

  Fly   374 KLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELS 438
            :.|.:|.|..|..|.:..|.|:::.|::|||..||..::.||.|:.|:..::|..:|:.||..:.
  Rat   364 RAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVI 428

  Fly   439 KN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVAL 502
            .| ||.:..:.:|.:..:|...||:.|::.||:|:.:.  .|..|:....:|..:.|||||.:..
  Rat   429 NNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHK--GAPHLRPAAHDLTWYQYHSLDVIGF 491

  Fly   503 IL---LPLILLILVLC-YLCK-----RNPSKLAHK 528
            :|   |.::.::...| |.|:     :...|.:||
  Rat   492 LLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	138/488 (28%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	136/484 (28%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	147/527 (28%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	145/525 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910