DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36A1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_444445.2	Gene:	Ugt2b37 / 112417	MGIID:	2148239	Length:	530	Species:	Mus musculus

Alignment Length:	523	Identity:	136/523 - (26%)
Similarity:	257/523 - (49%)	Gaps:	34/523 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVIS----YVKNPQAGAY 72
            ::||.|......:..|.:| |:| ..|||:..:..||:||..|||::||:.    ||.:|:....
Mouse     9 LLLLQISCCFRSVKCGKVL-VWP-MEFSHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPG 71

  Fly    73 PNYEELLISAPGEDQSSTTINLVPLTEHTPTR----SLGVLIREYVD-LHEEGQKTCEHLFASGH 132
            ..:|....|...:|..:..|.|:.:..:..:|    |...|::...| |.......|:.:.::..
Mouse    72 LKFETFPTSVTKDDLENFFIQLLNVWTYELSRDTCLSYSPLMQNMFDELSGYYLSLCKDVVSNRQ 136

  Fly   133 IERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYD----RIDLPDTPAF 193
            :...::..:   :|:||::......:| :|:||::|.: .|......|..:    |..||  |::
Mouse   137 LMTKLQESK---FDVLLSDPVAFGGEL-IAELLHIPFL-YSLRFTAGYRIEKSSGRFLLP--PSY 194

  Fly   194 IQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEEVARTQTAFIF 258
            :.....|..||:.:.||:.|.:......|.::..:::..:....:|||....:.|.......::.
Mouse   195 VPVILSGLGGQMTFIERVKNMICMLYFDFWFQMPNDKKWDSFYTEYLGRPTTLAETMGQAEMWLI 259

  Fly   259 GNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFISWGSMVRASSIDE 322
             ..::.|....|.......:||:|.  |..:.||:::..::..|.: ||:..|.||||  |:|.|
Mouse   260 -RSNWDLEFPHPTLPNVDYVGGLHC--KPAKPLPKDMEEYVQSSGDHGVVVFSLGSMV--SNITE 319

  Fly   323 DKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHGGLLGTTE 387
            :|::||...|...|.|::||::. :||.|........||.||..||.|||.|.|.:|||.....|
Mouse   320 EKVNAIAWALAQIPQKVLWKFDG-KTPATLGHNTRVYKWLPQNDLLGHPKTKAFITHGGANSVYE 383

  Fly   388 SVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKNS-YAQRSLEVSK 451
            :::.|.|::..|::|:|..|...:..:|..:.|:.:.::..::..||.|:.:|. |.:.::.:|.
Mouse   384 AIYHGIPMIGIPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIENPFYKKNAMWLST 448

  Fly   452 VFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALIL--LPLILLILVL 514
            :.:::...||:.|::.||.|:.:.  .|:.|:..|..|..:.|||||.:..:|  :...:::.|.
Mouse   449 IHHDQPMKPLDRAVFWVEFVMRHK--NAKHLRPLGHNLTWYQYHSLDVIGFLLACVAATVVLTVK 511

  Fly   515 CYL 517
            |.|
Mouse   512 CLL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	123/477 (26%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	125/477 (26%)
Ugt2b37	NP_444445.2	UDPGT	24..527	CDD:278624	133/508 (26%)
		Glycosyltransferase_GTB_type	42..>174	CDD:299143	32/136 (24%)
		egt	<270..489	CDD:223071	68/225 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840