Protein Alignment Ugt36A1 and UGT2B11

DIOPT Version :10

• Sequence 1: NP_524686.3
• Gene: Ugt36A1 / 44058
• FlyBaseID: FBgn0015663
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001064.1
• Gene: UGT2B11 / 10720
• HGNCID: 12545
• Length: 529
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 127/547 - (23%)
• Similarity: 246/547 - (44%)
• Gaps: 75/547 - (13%)

  Fly    25 SAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI----SYVKNPQAGAYPNYEELLISAPGE 85
            |.|.:|.....  :||:..:..||.||..|||::||:    |.:.:|                 .
Human    22 SCGKVLVWAAE--YSHWMNMKTILKELVQRGHEVTVLASSASILFDP-----------------N 67

  Fly    86 DQSSTTINLVPLTEHTPTRSLGVL---IREYVDLHEEG-------------------QKTCEHLF 128
            |.|:....:.| |..|.|....::   ::.:.|:.::.                   :..|:.:.
Human    68 DASTLKFEVYP-TSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELYDIFRNFCKDVV 131

  Fly   129 ASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMP-YYYDR----IDLP 188
            ::..:.:.::..|   :|::..:.. ..|...||.|||:..:  .:....| |..:|    :..|
Human   132 SNKKVMKKLQESR---FDIVFADAV-FPCGELLAALLNIRFV--YSLRFTPGYTIERHSGGLIFP 190

  Fly   189 DTPAFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEEVARTQ 253
              |::|.......:.|:.:.||:.|.:......|.::....:..::...:.||....:.|.....
Human   191 --PSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVLGRPTTLFETMGKA 253

  Fly   254 TAFIFGNQHYSLMGSRP--QSLQFVEIGGVHITKKAEQELPQNIANFLNQSAE-GVIFISWGSMV 315
            ..::..|. :|.....|  .::.||  ||.|.  |..:.||:.:..|:..|.| ||:..|.||::
Human   254 DIWLMRNS-WSFQFPHPFLPNVDFV--GGFHC--KPAKPLPKEMEEFVQSSGENGVVVFSLGSVI 313

  Fly   316 RASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLALLCHPKVKLFWSHG 380
              |::..::.:.|...|...|.|::|:::.:: ||.........||.||..||.|||.:.|.:||
Human   314 --SNMTAERANVIATALAKIPQKVLWRFDGNK-PDALGLNTRLYKWIPQNDLLGHPKTRAFITHG 375

  Fly   381 GLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKNS-YAQ 444
            |..|..|:::.|.|::..|::.||..|...::.:|..::||:..::..:|..||..:..:. |.:
Human   376 GANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKE 440

  Fly   445 RSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHSLDSVALILLPLIL 509
            ..:::|::.:::...||:.|::.:|.|:.:.  .|:.|:....:|..|.|||||.:..:|..:..
Human   441 NIMKLSRIQHDQPVKPLDRAVFWIEFVMPHK--GAKHLRVAAHDLTWFQYHSLDVIGFLLACVAT 503

  Fly   510 LILVLCYLCKRNPSKLAHKKVGKKPKR 536
            :|.::...|.....|.|.|  |||.||
Human   504 VIFIITKFCLFCFWKFARK--GKKGKR 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_524686.3	GT1_Gtf-like	28..469	CDD:340817	103/475 (22%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	122/540 (23%)