DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36A1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	566	Identity:	133/566 - (23%)
Similarity:	253/566 - (44%)	Gaps:	88/566 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVI-----SYVKNPQA 69
            |::..|.:|.:......||||..|..  .||:..:..:|:.|..|||::||:     .::|..::
Zfish     3 LVVCFLSLLTVFSAGQCGNILVWYTE--GSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKES 65

  Fly    70 GAYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIR-EYVDLHEEGQ----KTCEHLFA 129
            ..: :|:...:|...:|.......|:..:......|..:.|: ::.:|..:.|    ..|:.:..
Zfish    66 DRF-SYQHFSVSKSAQDMQDFFDELMRFSVFEMDNSSFLEIQMKFFNLGSQHQDMSLSYCDGILK 129

  Fly   130 SGHIERAIERHRNKPYDLLLTE--YFNSDCQLALAKLLNLPIIGLSTCALMPYYY--------DR 184
            |..:   :::.:...:|::|::  |   .|...:|:.||:|::         |.:        :|
Zfish   130 SPEL---MDKLKKGKFDVVLSDPMY---PCSDIVAEELNVPLV---------YTFRFSVAHAAER 179

  Fly   185 I--DLPDTPAFIQSEFVGFAGQLNWHERLLNFV----QAKLLKFLYKYHSNRADNELVRKYLGVE 243
            :  .:|..|:::.........::::.||:.|.:    |..|.:.:::    |.|| ...:|.|..
Zfish   180 MCGQIPAPPSYVPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIWR----RFDN-YYTEYFGRS 239

  Fly   244 VDVEE--------VARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLN 300
            ....|        :.||...|.|         .||....|..|||:|.|  ..:.||:::..|:.
Zfish   240 TSYCEMMGKADIWLIRTYWDFEF---------PRPFVPNFKYIGGLHCT--PAKPLPKDMEEFVQ 293

  Fly   301 QSA-EGVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQ 364
            .|. :|::..:.|||:  ..:.::..:.|...|...|.|::|:: ..|.|||........||.||
Zfish   294 SSGDDGIVVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRY-GGEKPDTLGENTRIYKWIPQ 355

  Fly   365 LALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPN 429
            ..||.|||.:.|.:|||..|..|:::.|.|::..|::|||..|...:..|...:.:|......|.
Zfish   356 NDLLGHPKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQ 420

  Fly   430 --LKKALAELSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGF 492
              :.|....::..||.:.::.:|::.::|...||:.:::.:|.|:.|.  .|:.|:.....|..:
Zfish   421 ELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNK--GAKHLRVEAHNLTWY 483

  Fly   493 VYHSLDSVALILLPLILLILVLCY---------LCKRNPSKLAHKK 529
            .||.|| |...|..::.|:|.:|:         .|.|  ||...||
Zfish   484 QYHCLD-VFAFLTTVLTLVLYICFKMAKFFIMRCCFR--SKRKSKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	114/501 (23%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	114/499 (23%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	128/544 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910