DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PSG8 and side-VII

DIOPT Version :9

Sequence 1:	NP_874366.1	Gene:	PSG8 / 440533	HGNCID:	9525	Length:	426	Species:	Homo sapiens
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	448	Identity:	110/448 - (24%)
Similarity:	163/448 - (36%)	Gaps:	105/448 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    25 LNFWNPPTTAQVTIE-----AQPTKV---SEGKDVLLLVHNLPQNLTGY-----IWYKGQIR--- 73
            ||..:||  .||.|.     .:.|.|   |||..|.|..    |.:.||     .||:..|.
  Fly   132 LNVISPP--KQVIIRDSSNVERSTVVGPYSEGDIVSLKC----QVIGGYPTPTISWYRDGIEIPC 190

Human    74 DLYHYITSYVVDGQIIIYGPAYSGRETIYSNASL---------LIQNVTQEDAGSYTLHI-IMGG 128
            :|.|.....:::.:|.:  |:. |||.:.|..:.         :::.|.|.|.....|:| ::|.
  Fly   191 ELSHLAGGKIIECEITL--PSL-GREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGA 252

Human   129 DENRGVTGHFTFTLYLETPKPSISSSKLNPREAMEAVSLTCDP--ETPDASYLWWMNGQSLPMSH 191
            .:                           |..|.....|.|..  ..|.|...||.||..|..:.
  Fly   253 HQ---------------------------PLSAGRRYDLLCQSAGSRPPAVITWWQNGIRLEKTT 290

Human   192 RLQLSETNRTLFLLGV--TKYTAGPY-ECEIRNPVSASR--SDPFTLNLLPKLPKPYITI-NNLK 250
            ....|:.|:|...|.:  :|..||.| .|:..|....|.  .|.:.|: :..:|:.|:.: .:|.
  Fly   291 ETTSSDGNQTTSTLSISLSKSDAGKYLSCKAYNHAVPSEPLEDGWKLD-IQYVPEAYVRLGTSLD 354

Human   251 P---RENKDVLNFTCEPKSE-NYTYIWWLNGQSLPVSPRVKRP--IENRILILPSVTRNETGPYQ 309
            |   ||..||. |.|...:. |...|.|.:.:. |:|..:...  |.|..|:|..|||...|.|.
  Fly   355 PSTLREGTDVY-FDCLVMAHPNVFRIEWRHNEQ-PLSHNISLGVIISNHSLVLQGVTRATAGNYS 417

Human   310 CEIRDQYGGIRSYPVTLNVLYGPDLPRIYPSFTYYRSGEVLYLSCSADSNP-PAQYSWTINGKFQ 373
            |...:..|...|.|..||:||.|...:...........|...:.|:.|:|| ..::|||.|...:
  Fly   418 CVGFNAEGEGISAPFALNILYAPTCAQNQKKVYGIAKQEDAKVMCTVDANPREVEFSWTFNNSAE 482

Human   374 ----------LSGQKLFI--PQITTKHSGLYACSVRNSATGKESSKSMTVKVSGKRIP 419
                      .||....:  ..||....|...|...|             |:..:|:|
  Fly   483 SIDVATNHIIRSGTTSIVTYTPITELDYGTLLCLASN-------------KIGKQRVP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSG8	NP_874366.1	Ig_CEACAM_D1	36..138	CDD:319315	29/127 (23%)
		Ig	148..236	CDD:325142	24/94 (26%)
		Ig	241..329	CDD:325142	29/94 (31%)
		Ig_2	335..413	CDD:316418	16/90 (18%)
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	1/1 (100%)
		V-set	32..134	CDD:284989	1/1 (100%)
		IGc2	160..>214	CDD:197706	16/60 (27%)
		Ig	262..328	CDD:299845	19/65 (29%)
		IG_like	264..323	CDD:214653	18/58 (31%)
		IGc2	360..425	CDD:197706	20/66 (30%)
		Ig_3	456..519	CDD:290638	15/62 (24%)
		FN3	538..620	CDD:238020
		FAM176	643..741	CDD:291517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910