DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PSG8 and Ceacam2

DIOPT Version :9

Sequence 1:	NP_874366.1	Gene:	PSG8 / 440533	HGNCID:	9525	Length:	426	Species:	Homo sapiens
Sequence 2:	NP_001106839.1	Gene:	Ceacam2 / 26367	MGIID:	1347246	Length:	520	Species:	Mus musculus

Alignment Length:	416	Identity:	164/416 - (39%)
Similarity:	205/416 - (49%)	Gaps:	101/416 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGLLSAPPCTQRITWKGLLLTASLLNFWNPPTTAQVTIEAQPTKVSEGKDVLLLVHNLPQNLTGY 65
            |.|.||.....::.|.|||||||||..|:||||||||:.|.|...:||.:|:|:|:|:.:.::.:
Mouse     1 MELASAHLHKGQVPWFGLLLTASLLASWSPPTTAQVTVMAFPLHAAEGNNVILVVYNMMKGVSAF 65

Human    66 IWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETIYSNASLLIQNVTQEDAGSYTLHIIMGGDE 130
            .|:||........|..:|......|.||.:|||||:|||.|||||.||.:|.|.||:.:......
Mouse    66 SWHKGSTTSTNAEIVRFVTGTNKTIKGPVHSGRETLYSNGSLLIQRVTMKDTGVYTIEMTDQNYR 130

Human   131 NRGVTGHF-TFTLYLETPKPSISSSKLNPREAMEAVSLTCDPET-PD-ASYLWWMNGQSLPMSHR 192
            .|.:||.| ..||.|   |.:|:|:..||.|..::||||||..| || .:|||..||:||....|
Mouse   131 RRVLTGQFHVHTLLL---KSNITSNNSNPVEGDDSVSLTCDSYTDPDNITYLWSRNGESLSEGDR 192

Human   193 LQLSETNRTLFLLGVTKYTAGPYECEIRNPVSASRSDPFTLNLLPKLPKPYITINNLKPRENKDV 257
            |:|||.||||.||.||:...|||.||.|||||.:|||||
Mouse   193 LKLSEGNRTLTLLNVTRNDTGPYVCETRNPVSVNRSDPF-------------------------- 231

Human   258 LNFTCEPKSENYTYIWWLNGQSLPVSPRVKRPIENRILILPSVTRNETGPYQCEIRDQYGGIRSY 322

Mouse   232 ----------------------------------------------------------------- 231

Human   323 PVTLNVLYGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINGKFQLSGQKLFIPQITTK 387
              :||::||||.|.|.||..|...|..|.|||.|.|||||||.|.||.|...|.|:||||.|||.
Mouse   232 --SLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQYFWLINEKPHASSQELFIPNITTN 294

Human   388 HSGLYACSVRNSATG--KESSKSMTV 411
            :||.|.|.|.||.||  :.:.|::||
Mouse   295 NSGTYTCFVNNSVTGLSRTTVKNITV 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSG8	NP_874366.1	Ig_CEACAM_D1	36..138	CDD:319315	40/101 (40%)
		Ig	148..236	CDD:325142	50/89 (56%)
		Ig	241..329	CDD:325142	2/87 (2%)
		Ig_2	335..413	CDD:316418	43/79 (54%)
Ceacam2	NP_001106839.1	Ig_CEACAM_D1	36..140	CDD:143251	41/103 (40%)
		Ig	146..235	CDD:299845	51/181 (28%)
		IG_like	157..221	CDD:214653	35/63 (56%)
		Ig_2	242..320	CDD:290606	41/77 (53%)
		IG_like	246..320	CDD:214653	39/73 (53%)
		Ig	322..412	CDD:299845
		IG_like	333..412	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..520
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965293
Domainoid	1	1.000	96	1.000	Domainoid score	I46009
eggNOG	1	0.900	-	-		E1_29WEF
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D241176at32523
OrthoFinder	1	1.000	-	-		FOG0000658
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44427
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850