DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PSG8 and si:ch211-264f5.6

DIOPT Version :9

Sequence 1:	NP_874366.1	Gene:	PSG8 / 440533	HGNCID:	9525	Length:	426	Species:	Homo sapiens
Sequence 2:	XP_002665524.2	Gene:	si:ch211-264f5.6 / 100319064	ZFINID:	ZDB-GENE-081104-208	Length:	540	Species:	Danio rerio

Alignment Length:	491	Identity:	113/491 - (23%)
Similarity:	179/491 - (36%)	Gaps:	150/491 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    48 GKDVLL--LVHNLPQNLT-GYIWYKGQIRDLYHYITSYVVDGQIIIYGPAYSGRETIYSNAS--- 106
            ||:|..  .|.:.|..|| .:.:.|||...:...|.|    ...:...|.|..|  |..|.:
Zfish    36 GKNVTFKTTVVSTPDILTVTWTFNKGQPIAMVTVIPS----SNTVSVRPPYVNR--ISCNRTTFQ 94

Human   107 LLIQNVTQEDAGSYTLHIIMGGDENRG--VTGHFTFTLYLETPKPSISSSKLNPREAMEAVSLTC 169
            |.:..:.:||.|.|.|.|:    .|.|  |||.....:........|||:.|.|.|....|.|||
Zfish    95 LQLGPLVKEDTGEYILTIV----TNNGDLVTGQIDLEVLEPVTDVKISSNVLEPVEFNSTVVLTC 155

Human   170 DPETPDASYLW-WMNGQSLPM------------SHRLQLSETNRTLFLLGVTKYTAGPYECEIRN 221
            ..:   .|:.: |:|| |:|:            .:.|::||..||        ...||..|...|
Zfish   156 SAK---GSFTYKWING-SVPLVVDGTHMQLNAVGNELKISEVRRT--------DLQGPIVCIAEN 208

Human   222 PVSASRSDPFTL-----------NLLP--------------------------------KLPKPY 243
            .:.:.:|.||.|           |..|                                .||...
Zfish   209 ALESGKSAPFNLTVSYGPENILMNQFPTDTYLKKGSTLTLTCTADSNPPATIQWVFNGVNLPSNA 273

Human   244 I------TINNLKPRENKDVLNFTC---EPKSENY------------------------------ 269
            :      |:|||   |.|:..|:||   ..:::.|
Zfish   274 VSSPANFTLNNL---EEKNSGNYTCVAYNAQTKRYIASRVAFVTVVESLSGTNISSSTSLLIAGN 335

Human   270 ---------------TYIWWLNGQSLPVSPRVKRPIENRILILPSVTRNETGPYQCEIRDQYG-G 318
                           |..|..:|:.|....|:....:...:.:..|.:.:.|.|:|.:|::.. .
Zfish   336 STVNLTCFAAAGRAETVEWVKDGKPLNPDSRIVFSADKTSVSIDKVVKEDRGEYRCLLRNKVNKD 400

Human   319 IRSYPVTLNVLYGPDLPRIYPSFTYYRSGEVLYLSCSADSNPPAQYSWTINGKFQLSGQKLF-IP 382
            ..||.:.:|  |||:...:..........:| .|||:|:|.||:.|:|.:||....|.|::: :.
Zfish   401 EASYNLKIN--YGPEKVAVQGKHAVKFEDDV-ELSCTAESVPPSTYTWKLNGTALNSSQQVYVVK 462

Human   383 QITTKHSGLYACSVRNSATGK--ESSKSMTVKVSGK 416
            :...:.||:|.|...|:.|||  :::..:.|...||
Zfish   463 RAKDRDSGIYTCEAFNNITGKMDKTTHKLAVTTDGK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSG8	NP_874366.1	Ig_CEACAM_D1	36..138	CDD:319315	29/97 (30%)
		Ig	148..236	CDD:325142	30/111 (27%)
		Ig	241..329	CDD:325142	23/142 (16%)
		Ig_2	335..413	CDD:316418	23/80 (29%)
si:ch211-264f5.6	XP_002665524.2	Ig	33..129	CDD:299845	29/102 (28%)
		IG_like	33..128	CDD:214653	29/101 (29%)
		Ig	130..222	CDD:299845	29/103 (28%)
		IG_like	149..222	CDD:214653	23/84 (27%)
		I-set	233..315	CDD:254352	13/84 (15%)
		Ig_2	235..315	CDD:290606	13/82 (16%)
		IGc2	335..398	CDD:197706	10/62 (16%)
		Ig_2	427..494	CDD:290606	22/67 (33%)
		IG_like	427..479	CDD:214653	18/52 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_29WEF
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312709at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6720
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.780