Protein Alignment Shc and Shc1

DIOPT Version :10

• Sequence 1: NP_524683.2
• Gene: Shc / 44052
• FlyBaseID: FBgn0015296
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001157532.1
• Gene: Shc1 / 85385
• RGDID: 620446
• Length: 579
• Species: Rattus norvegicus
• Alignment Length: 466
• Identity: 185/466 - (39%)
• Similarity: 240/466 - (51%)
• Gaps: 95/466 - (20%)

  Fly     5 GDAGNRSGS--GTTSDGCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRV 67
            |:...|.||  ...:.|.::|:|.:||.||::.|||.|||||..||::|||.||||:.||.|:.|
  Rat   131 GEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLV 195

  Fly    68 CEAA-GLKSAGKRR------LTNFISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPR 125
            |||. |.|.|.:||      |::.:. |.:::.||..|.:.||:.:|:|...:..::||||:|..
  Rat   196 CEAVPGAKGAMRRRKPCSRPLSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQS 259

  Fly   126 ISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDP--- 187
            ||||||||.||.:::||:||:....|||::|||..|.::|:|.|||:||.|||....| |.|
  Rat   260 ISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLR-NPPKLV 323

  Fly   188 ---SADCNINQSCKENVKE------YYNDLPNKLPP-----------EVPEPQQQQVQQPLH--- 229
               ......:.|..:..:|      ||||.|.|.||           ....|.....|.|.|
  Rat   324 TPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAARPTLPSTQMPSHLGA 388

  Fly   230 ----------PHAPRVAQLNLKKPRDRLSSNLIDLNSPPP--------DQTTNKLGHFDPL-QAT 275
                      .|..|...|                 .|||        |.:...:.:.|.. ||.
  Rat   389 TLPIGQHVTGDHEVRKQML-----------------PPPPCPGRELFDDPSYVNIQNLDKARQAG 436

  Fly   276 TAANSVLPSV-----RDVFD------------GPQC-----PLTAEVWFHAGISRPISERLLQQD 318
            ..|....|||     ||:||            .||.     .|..|.|||..:||..:|.|||.:
  Rat   437 GGAGPPNPSVNGSAPRDLFDMKPFEDALRVPPAPQSMSMAEQLQGESWFHGKLSRREAEALLQLN 501

  Fly   319 GDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTKDRIFDSISHLINYHWAHALPIISED 383
            ||||||||....||||||||:...||||||:||||||||||..|:|:||||:||..:.|||||..
  Rat   502 GDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAG 566

  Fly   384 SELVLRNPVRR 394
            |||.|:.||.|
  Rat   567 SELCLQQPVDR 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	79/165 (48%)
		SH2_SHC	293..396	CDD:198179	64/107 (60%)
Shc1	NP_001157532.1	PTB_Shc	146..317	CDD:269920	81/171 (47%)
		SH2_SHC	476..578	CDD:198179	63/102 (62%)