DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shc and Shc4

DIOPT Version :9

Sequence 1:	NP_524683.2	Gene:	Shc / 44052	FlyBaseID:	FBgn0015296	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001177994.1	Gene:	Shc4 / 679845	RGDID:	1583644	Length:	622	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	170/477 - (35%)
Similarity:	245/477 - (51%)	Gaps:	113/477 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKNGDAGNRSGSGTTSDGCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECIN 65
            :|..|:...||    ..||  .|...::|.|:.:.|||.||:||..||:||||..|||:.||.|:
  Rat   165 LPGPGEPNPRS----KQDG--PPLQHLLGNGLNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAIS 223

  Fly    66 RVCEAA-GLKSAGKRR------LTNFISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNM 123
            |:|||. |:..|.|:|      ||..:. :.::|.:|.||.:.||:.:|:|.|::..::||||.|
  Rat   224 RLCEAVPGVHGAIKKRKAPVKFLTTVLG-KSNLQFSGMNIKLTVSTSSLTLMNLDNQQIIANHQM 287

  Fly   124 PRISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDPS 188
            ..||||||||.||.|::||:||:....|||::|||..|.::|:|.|||:||.|||.  ..|.:||
  Rat   288 QSISFASGGDPDTTDYVAYVAKDPVNQRACHILECRSGTAQDIISTIGQAFELRFK--QYLKNPS 350

  Fly   189 ------ADCNINQSCKENVKEYYNDLPNKLPPEVPEPQQQQVQQPLHPHAPRVAQLNLKKPRDRL 247
                  .:..::.:.::...:|||.:|.|.||                 |..:|.:.::...|.:
  Rat   351 LNTWEREEVLVDGTSEDRGHDYYNSIPGKQPP-----------------AGGIADVRIQVQADPV 398

  Fly   248 S------SNLIDLNSPPPDQTT------NKLGHFDP--LQATTAANSVLPSVR-----DVFDGP- 292
            :      ..|..|    |..:|      |.:|...|  :....|..|...|:|     |:||.|
  Rat   399 AYCPIRCEKLCYL----PGTSTCSGVYKNCMGRSRPIGIPHERAMQSDAASLRHFWRVDLFDDPC 459

  Fly   293 ---------------------------QCPLTA-------------------EVW----FHAGIS 307
                                       :.|.|.                   ::|    ||..:|
  Rat   460 YVNTQNMRGCAGNQSSTLPQGSPWHLGKAPETVQPGATAKPGSSHALPHIKQQLWSEECFHGRLS 524

  Fly   308 RPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTKDRIFDSISHLINYH 372
            |..:||||.:|||||||||....||:||:||:|...|||||:||||.|||||.:||::.|||.||
  Rat   525 RGAAERLLVKDGDFLVRESVTSPGQFVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIKYH 589

  Fly   373 WAHALPIISEDSELVLRNPVRR 394
            ..::|||||..||:.|:.||::
  Rat   590 MDNSLPIISSGSEVSLKQPVKK 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	77/165 (47%)
Shc	NP_524683.2	SH2_SHC	293..396	CDD:198179	58/125 (46%)
Shc4	NP_001177994.1	PTB_Shc	181..347	CDD:269920	78/168 (46%)
Shc4	NP_001177994.1	SH2_SHC	510..609	CDD:198179	54/98 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353524
Domainoid	1	1.000	143	1.000	Domainoid score	I4524
eggNOG	1	0.900	-	-		E1_KOG3697
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H19567
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2835
OMA	1	1.010	-	-		QHG49816
OrthoDB	1	1.010	-	-		D1351843at2759
OrthoFinder	1	1.000	-	-		FOG0001057
OrthoInspector	1	1.000	-	-		otm44613
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10337
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X710
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870