Protein Alignment Shc and SHC1

DIOPT Version :10

• Sequence 1: NP_524683.2
• Gene: Shc / 44052
• FlyBaseID: FBgn0015296
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: XP_005245506.1
• Gene: SHC1 / 6464
• HGNCID: 10840
• Length: 598
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 159/416 - (38%)
• Similarity: 217/416 - (52%)
• Gaps: 69/416 - (16%)

  Fly     5 GDAGNRSGS--GTTSDGCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRV 67
            |:...|.||  ...:.|.::|:|.:||.||::.|||.|||||..||::|||.||||:.||.|:.|
Human   131 GEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLV 195

  Fly    68 CEAA-GLKSAGKRR------LTNFISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPR 125
            |||. |.|.|.:||      |::.:. |.:::.||..|.:.||:.:|:|...:..::||||:|..
Human   196 CEAVPGAKGATRRRKPCSRPLSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQS 259

  Fly   126 ISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDP--- 187
            ||||||||.||.:::||:||:....|||::|||..|.::|:|.|||:||.|||....| |.|
Human   260 ISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLR-NPPKLV 323

  Fly   188 ---SADCNINQSCKENVKE------YYNDLPNKLPPEVPEPQQQQVQQPLHPHAPRVAQLNLKKP 243
               ......:.|..:..:|      ||||.|.|.|| :......::::...|.|.|....|.:.|
Human   324 TPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPP-LGGVVDMRLREGAAPGAARPTAPNAQTP 387

  Fly   244 RDRLSSNL-----------IDLNSPPPDQTTNKLGHFDP-----------LQATTAANSVLPSV- 285
             ..|.:.|           :....|||.....:....||           .||...|....|::
Human   388 -SHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAIN 451

  Fly   286 ----RDVFD------------GPQC-----PLTAEVWFHAGISRPISERLLQQDGDFLVRESQGK 329
                ||:||            .||.     .|..|.|||..:||..:|.|||.:||||||||...
Human   452 GSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTT 516

  Fly   330 RGQYVLTGLEGKTPKHLLLIDPEGVV 355
            .||||||||:...||||||:||||||
Human   517 PGQYVLTGLQSGQPKHLLLVDPEGVV 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	79/165 (48%)
		SH2_SHC	293..396	CDD:198179	40/68 (59%)
SHC1	XP_005245506.1	PTB_Shc	146..317	CDD:269920	81/171 (47%)
		SH2_SHC	480..583	CDD:198179	39/63 (62%)