DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shc and shc2

DIOPT Version :9

Sequence 1:	NP_524683.2	Gene:	Shc / 44052	FlyBaseID:	FBgn0015296	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	XP_017208646.1	Gene:	shc2 / 562011	ZFINID:	ZDB-GENE-050208-666	Length:	679	Species:	Danio rerio

Alignment Length:	488	Identity:	179/488 - (36%)
Similarity:	248/488 - (50%)	Gaps:	108/488 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GDAGNRSGS--GTTSDGCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRV 67
            ||...:.||  ...|.|.::||..|...|.::.|||.||:||..||:||||.||||:.||.|||:
Zfish   200 GDNFTQKGSFINKPSQGWLHPDKKISSTGASYIVRYMGCIEVLKSMRSLDFSTRTQVTREAINRL 264

  Fly    68 CEAA-GLKSAGKRRLTN----FISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRIS 127
            ||:. |.|:|.|::.||    .|..:.:::.||.:|.:|:|...|||....|.:|||:|.|..||
Zfish   265 CESVPGGKTAWKKKTTNKTLQSIMGKSNLRFAGMSIGVNISIDGLSLLVPTTRQVIAHHPMQSIS 329

  Fly   128 FASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFNALSRLND-----P 187
            ||||||:||.|::||:||:....|||::|||..|.::::|.|||:||.|:|.  ..|:.     |
Zfish   330 FASGGDSDTPDYVAYVAKDPVNQRACHILECCDGLAQNVISTIGQAFELQFK--QYLHSPPKAIP 392

  Fly   188 SADCNI-------NQSCKENVKEYYNDLPNKLPPEVPEPQQQQVQQP------LHPHAPRVAQLN 239
            :.|.||       .:..:.:..:|||.:|.|.|| |......:::.|      :|.| |:.....
Zfish   393 AMDRNIRTEESAWGEDEESSEHDYYNSIPGKEPP-VGGVVDSRLRPPAGLLGHVHTH-PQSKTSQ 455

  Fly   240 LKKPRDRLSSNLIDLNSPPP---------DQTTNKL-------------GH-------------- 268
            :..|..|      |.||.|.         |...|:.             ||
Zfish   456 MGSPAKR------DANSLPATHLCYEVHWDTENNRSSTGLTSDGYLRADGHPPGSRDYEEHLYVN 514

  Fly   269 ---FDPLQATTAANSVLPSVRDVFD------------------------------GPQCP----L 296
               .|.|:|:..........:|:||                              .|..|    |
Zfish   515 TQNLDNLEASVVGRRPESPKKDIFDMRPFEDALRLHEASGVCVLEDKWPSPPRRRAPVAPTEDQL 579

  Fly   297 TAEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTKDRI 361
            ..|:|:|..:||..:|.||.:|||||||:|....|||||||::...||||||:||||||||||.:
Zfish   580 RREMWYHGRMSRRDAENLLGRDGDFLVRDSATNPGQYVLTGMQCGLPKHLLLVDPEGVVRTKDML 644

  Fly   362 FDSISHLINYHWAHALPIISEDSELVLRNPVRR 394
            |:|||||||||..:.|||::.:|||.|:..|.|
Zfish   645 FESISHLINYHLTNKLPIVAAESELHLQQVVCR 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	79/163 (48%)
Shc	NP_524683.2	SH2_SHC	293..396	CDD:198179	60/106 (57%)
shc2	XP_017208646.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595654
Domainoid	1	1.000	141	1.000	Domainoid score	I4654
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3036
OMA	1	1.010	-	-		QHG49816
OrthoDB	1	1.010	-	-		D1351843at2759
OrthoFinder	1	1.000	-	-		FOG0001057
OrthoInspector	1	1.000	-	-		otm25768
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10337
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8103
SonicParanoid	1	1.000	-	-		X710
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.040