Protein Alignment Shc and SHC3

DIOPT Version :10

• Sequence 1: NP_524683.2
• Gene: Shc / 44052
• FlyBaseID: FBgn0015296
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_058544.3
• Gene: SHC3 / 53358
• HGNCID: 18181
• Length: 594
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 176/464 - (37%)
• Similarity: 240/464 - (51%)
• Gaps: 95/464 - (20%)

  Fly    19 GCIYPDDVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAA-GLKSAGKRR-- 80
            |..:..|.::|.||.:.|:|.||:||..||:||||.||||:.||.|:|||||. |.|.|.|:|
Human   140 GAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKP 204

  Fly    81 ---LTNFISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRISFASGGDNDTLDFLAY 142
               :.:.|..:.::|.||.:|.:.:|:.:|:|...::.::||||:|..||||||||.||.|::||
Human   205 PSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAY 269

  Fly   143 IAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRF-------NALSRLNDPSADCNINQSCKEN 200
            :||:....|||::|||..|.::|:|.:||:||.|||       ..:..|:|..      ||..|.
Human   270 VAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRM------QSLDEP 328

  Fly   201 VKE---------YYNDLPNKLPPEVPEPQQQQVQQPLHPHAPRVAQLNLKKPRDRLSSNLIDLNS 256
            ..|         |||.:|:|:||  |........:| .||||..||...|:.......:|.|...
Human   329 WTEEEGDGSDHPYYNSIPSKMPP--PGGFLDTRLKP-RPHAPDTAQFAGKEQTYYQGRHLGDTFG 390

  Fly   257 PPPDQTTNKLGHFD--------------------------PLQATTAANSVLPSV--RDVFD--- 290
            ....||..:.|..|                          |.||..||.|...|.  :|:||
Human   391 EDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKP 455

  Fly   291 --------------------------GPQCP-------LTAEVWFHAGISRPISERLLQQDGDFL 322
                                      .|:.|       |.||.|:...:||..:|.||::|||||
Human   456 FEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFL 520

  Fly   323 VRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTKDRIFDSISHLINYHWAHALPIISEDSELV 387
            ||:|....|.:||||:.....|||||:||||.:|||||:|||||||||:|...:|||:|..|||.
Human   521 VRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELC 585

  Fly   388 LRNPVRRPQ 396
            |:.||.|.|
Human   586 LQQPVERKQ 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	76/164 (46%)
		SH2_SHC	293..396	CDD:198179	58/109 (53%)
SHC3	NP_058544.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	98..147		1/6 (17%)
		PTB_Shc	139..310	CDD:269920	78/169 (46%)
		CH1	335..498		36/165 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	351..373		9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..405		4/18 (22%)
		SH2_SHC	492..594	CDD:198179	57/101 (56%)