DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shc and SHC4

DIOPT Version :9

Sequence 1:	NP_524683.2	Gene:	Shc / 44052	FlyBaseID:	FBgn0015296	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_976224.3	Gene:	SHC4 / 399694	HGNCID:	16743	Length:	630	Species:	Homo sapiens

Alignment Length:	489	Identity:	172/489 - (35%)
Similarity:	248/489 - (50%)	Gaps:	111/489 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PKNGDAGNRSGSGTTSDGCIYPD---------------DVIMGVGVAFNVRYTGCVEVKTSMKSL 51
            |:....|:|: :..|.|.|..|.               ..::|:|:.:.|||.|||||..||:||
Human   146 PQQDLVGHRA-TALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSL 209

  Fly    52 DFETRTQLARECINRVCEAA-GLKSAGKRRL--TNFIS---DRPSMQHAGTNIIINVSSRALSLS 110
            ||..|||:.||.|:|:|||. |...|.|:|.  ..|:|   .:.::|.:|.||.:.:|:.:|:|.
Human   210 DFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLM 274

  Fly   111 NVETGEVIANHNMPRISFASGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFA 175
            |::..::||||:|..||||||||.||.|::||:||:....|||::|||..|.::|:|.|||:||.
Human   275 NLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFE 339

  Fly   176 LRFNALSRLNDPSADCNINQSCK-ENV-----------KEYYNDLPNKLPP-----------EVP 217
            |||.  ..|.:||    :|.||: |.|           .||||::|.|.||           :..
Human   340 LRFK--QYLKNPS----LNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQAT 398

  Fly   218 EP----------------------------QQQQVQQPLHPHAPRVAQLNLKKPRDRLSSNLID- 253
            |.                            :|.:....:||...: :|.:....:.....:|.|
Human   399 EQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQ-SQRDTSLLKHTCRVDLFDD 462

  Fly   254 ---LNSPPPDQTTNKLGH---FDPL-----------------QATTAANSVLPSVRDVFDGPQCP 295
               :|:.....|....|:   ..||                 .|..|::..||.::......:|
Human   463 PCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEEC- 526

  Fly   296 LTAEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTKDR 360
                  :|..:||..:|.||.:|||||||||....|||||:||:|...|||||:||||.|||||.
Human   527 ------YHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDH 585

  Fly   361 IFDSISHLINYHWAHALPIISEDSELVLRNPVRR 394
            :||::.|||.||..::|||||..||:.|:.|||:
Human   586 VFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shc	NP_524683.2	PTB_Shc	19..178	CDD:269920	77/179 (43%)
Shc	NP_524683.2	SH2_SHC	293..396	CDD:198179	56/102 (55%)
SHC4	NP_976224.3	CH2	1..185		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..80
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..150		1/3 (33%)
		PTB_Shc	176..347	CDD:269920	77/172 (45%)
		CH1	370..525		24/155 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..514		6/42 (14%)
		SH2_SHC	518..618	CDD:198179	54/106 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159477
Domainoid	1	1.000	143	1.000	Domainoid score	I4651
eggNOG	1	0.900	-	-		E1_KOG3697
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H19567
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2905
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49816
OrthoDB	1	1.010	-	-		D1351843at2759
OrthoFinder	1	1.000	-	-		FOG0001057
OrthoInspector	1	1.000	-	-		otm40471
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10337
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X710
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870